Matches in SemOpenAlex for { <https://semopenalex.org/work/W935458382> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W935458382 endingPage "5" @default.
- W935458382 startingPage "694" @default.
- W935458382 abstract "Investigation was undertaken to produce a radioactive material with affinity for amyloid tissue. Studies of a number of major dyes using paraffin histological sections of an amyloid spleen as test material showed that the only compounds with marked affinity for amyloid were watersoluble disazo dyes of the type E<--D-->E, where D is usually benzidine, o-tolidine or o-dianisidine, and E is a naphthol or aminonaphthol sulfonic acid. Substitution of an amino or a hydroxyl group in position 1 of the naphthalene nucleus caused loss of staining affinity. It was found that trypan blue could be radioiodinated at position 8 using the Sandmeyer reaction, and the labelled dye showed excellent staining and radioautographs of the test amyloid section. Metabolism of the tagged dye using 10-200 mug./kg. in animals showed minimal organ uptake, except for the liver which accumulated 30-40% of the injected dose by the end of four days. Use of this material in the diagnosis of human amyloid disease is being explored." @default.
- W935458382 created "2016-06-24" @default.
- W935458382 creator A5006887965 @default.
- W935458382 creator A5021938458 @default.
- W935458382 creator A5051056282 @default.
- W935458382 date "1964-03-14" @default.
- W935458382 modified "2023-10-18" @default.
- W935458382 title "A RADIOIODINATED AZO DYE WITH AFFINITY FOR AMYLOID: A PRELIMINARY REPORT." @default.
- W935458382 cites W2395154073 @default.
- W935458382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1922433" @default.
- W935458382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14127385" @default.
- W935458382 hasPublicationYear "1964" @default.
- W935458382 type Work @default.
- W935458382 sameAs 935458382 @default.
- W935458382 citedByCount "0" @default.
- W935458382 crossrefType "journal-article" @default.
- W935458382 hasAuthorship W935458382A5006887965 @default.
- W935458382 hasAuthorship W935458382A5021938458 @default.
- W935458382 hasAuthorship W935458382A5051056282 @default.
- W935458382 hasConcept C142724271 @default.
- W935458382 hasConcept C1491633281 @default.
- W935458382 hasConcept C179104552 @default.
- W935458382 hasConcept C185592680 @default.
- W935458382 hasConcept C2777633098 @default.
- W935458382 hasConcept C2780070996 @default.
- W935458382 hasConcept C2780267503 @default.
- W935458382 hasConcept C43617362 @default.
- W935458382 hasConcept C55493867 @default.
- W935458382 hasConcept C71924100 @default.
- W935458382 hasConcept C74864618 @default.
- W935458382 hasConceptScore W935458382C142724271 @default.
- W935458382 hasConceptScore W935458382C1491633281 @default.
- W935458382 hasConceptScore W935458382C179104552 @default.
- W935458382 hasConceptScore W935458382C185592680 @default.
- W935458382 hasConceptScore W935458382C2777633098 @default.
- W935458382 hasConceptScore W935458382C2780070996 @default.
- W935458382 hasConceptScore W935458382C2780267503 @default.
- W935458382 hasConceptScore W935458382C43617362 @default.
- W935458382 hasConceptScore W935458382C55493867 @default.
- W935458382 hasConceptScore W935458382C71924100 @default.
- W935458382 hasConceptScore W935458382C74864618 @default.
- W935458382 hasLocation W9354583821 @default.
- W935458382 hasOpenAccess W935458382 @default.
- W935458382 hasPrimaryLocation W9354583821 @default.
- W935458382 hasRelatedWork W1970613475 @default.
- W935458382 hasRelatedWork W2011529878 @default.
- W935458382 hasRelatedWork W2022620934 @default.
- W935458382 hasRelatedWork W2107061803 @default.
- W935458382 hasRelatedWork W2323294422 @default.
- W935458382 hasRelatedWork W2360446563 @default.
- W935458382 hasRelatedWork W2387044450 @default.
- W935458382 hasRelatedWork W2801211806 @default.
- W935458382 hasRelatedWork W2953256015 @default.
- W935458382 hasRelatedWork W935458382 @default.
- W935458382 hasVolume "90" @default.
- W935458382 isParatext "false" @default.
- W935458382 isRetracted "false" @default.
- W935458382 magId "935458382" @default.
- W935458382 workType "article" @default.