Matches in SemOpenAlex for { <https://semopenalex.org/work/W935575462> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W935575462 endingPage "185" @default.
- W935575462 startingPage "180" @default.
- W935575462 abstract "This chapter discusses the microsomal vitamin K-dependent carboxylase. The physiological substrates for this enzyme are the liver microsomal precursor(s) of each of the vitamin K-dependent plasma proteins. Incorporation of CO2 into Glu residues of these endogenous substrates to form γ-carboxyGlu (Gla) residues can be followed as a vitamin K-dependent fixation of 14CO2 into trichloroacetic acid-precipitable protein. Various low-molecular-weight peptides containing Glu-Glu sequences are also substrates, and enzyme activity assayed with peptides as substrates can be followed by measuring the vitamin K-dependent incorporation of 14CO2 into nonvolatile, nontrichloroacetic acid-precipitable radioactivity. The microsomal vitamin K-dependent carboxylase is sensitive to high temperatures and is rapidly inactivated above 20°. Meaningful rates of carboxylation can therefore be measured only at 17° or below. Half-maximal activity of the enzyme is achieved at about 20 μg of vitamin KH2 per milliliter of incubation; at the standard incubation conditions of nearly 100 μg/ml, the enzyme is saturated with respect to this substrate. The enzyme activity is not increased by raising the O2 concentration above air saturation." @default.
- W935575462 created "2016-06-24" @default.
- W935575462 creator A5010696946 @default.
- W935575462 creator A5026880982 @default.
- W935575462 creator A5066393467 @default.
- W935575462 date "1980-01-01" @default.
- W935575462 modified "2023-10-12" @default.
- W935575462 title "[23] Microsomal Vitamin K-dependent carboxylase" @default.
- W935575462 cites W1596291267 @default.
- W935575462 cites W1623126220 @default.
- W935575462 cites W2010914555 @default.
- W935575462 cites W2074276743 @default.
- W935575462 doi "https://doi.org/10.1016/s0076-6879(80)67025-6" @default.
- W935575462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7366424" @default.
- W935575462 hasPublicationYear "1980" @default.
- W935575462 type Work @default.
- W935575462 sameAs 935575462 @default.
- W935575462 citedByCount "21" @default.
- W935575462 countsByYear W9355754622015 @default.
- W935575462 countsByYear W9355754622018 @default.
- W935575462 countsByYear W9355754622020 @default.
- W935575462 crossrefType "book-chapter" @default.
- W935575462 hasAuthorship W935575462A5010696946 @default.
- W935575462 hasAuthorship W935575462A5026880982 @default.
- W935575462 hasAuthorship W935575462A5066393467 @default.
- W935575462 hasConcept C140137476 @default.
- W935575462 hasConcept C161790260 @default.
- W935575462 hasConcept C181199279 @default.
- W935575462 hasConcept C185592680 @default.
- W935575462 hasConcept C18903297 @default.
- W935575462 hasConcept C24428623 @default.
- W935575462 hasConcept C25642318 @default.
- W935575462 hasConcept C2776940978 @default.
- W935575462 hasConcept C2777289219 @default.
- W935575462 hasConcept C2777332483 @default.
- W935575462 hasConcept C2780022331 @default.
- W935575462 hasConcept C28212737 @default.
- W935575462 hasConcept C43617362 @default.
- W935575462 hasConcept C55493867 @default.
- W935575462 hasConcept C86803240 @default.
- W935575462 hasConcept C87644729 @default.
- W935575462 hasConceptScore W935575462C140137476 @default.
- W935575462 hasConceptScore W935575462C161790260 @default.
- W935575462 hasConceptScore W935575462C181199279 @default.
- W935575462 hasConceptScore W935575462C185592680 @default.
- W935575462 hasConceptScore W935575462C18903297 @default.
- W935575462 hasConceptScore W935575462C24428623 @default.
- W935575462 hasConceptScore W935575462C25642318 @default.
- W935575462 hasConceptScore W935575462C2776940978 @default.
- W935575462 hasConceptScore W935575462C2777289219 @default.
- W935575462 hasConceptScore W935575462C2777332483 @default.
- W935575462 hasConceptScore W935575462C2780022331 @default.
- W935575462 hasConceptScore W935575462C28212737 @default.
- W935575462 hasConceptScore W935575462C43617362 @default.
- W935575462 hasConceptScore W935575462C55493867 @default.
- W935575462 hasConceptScore W935575462C86803240 @default.
- W935575462 hasConceptScore W935575462C87644729 @default.
- W935575462 hasFunder F4320332161 @default.
- W935575462 hasLocation W9355754621 @default.
- W935575462 hasLocation W9355754622 @default.
- W935575462 hasOpenAccess W935575462 @default.
- W935575462 hasPrimaryLocation W9355754621 @default.
- W935575462 hasRelatedWork W1239014656 @default.
- W935575462 hasRelatedWork W1535760802 @default.
- W935575462 hasRelatedWork W1963703261 @default.
- W935575462 hasRelatedWork W1977265717 @default.
- W935575462 hasRelatedWork W1996669795 @default.
- W935575462 hasRelatedWork W1999139068 @default.
- W935575462 hasRelatedWork W2041555974 @default.
- W935575462 hasRelatedWork W2160820505 @default.
- W935575462 hasRelatedWork W2280410841 @default.
- W935575462 hasRelatedWork W4252318192 @default.
- W935575462 isParatext "false" @default.
- W935575462 isRetracted "false" @default.
- W935575462 magId "935575462" @default.
- W935575462 workType "book-chapter" @default.