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• W935590972 abstract "BACKGROUND/AIM: Recently, low-dose aspirin (ASA) has been widely used as the firstchoice drug for the prophylaxis and treatment of thrombosis. Enteric-coated (EC) ASA has been used to limit gastric lesions as a side effect, but even low doses of EC ASA often cause mucosal damage in the small intestine in humans. However, there are few studies on the ulcerogenic effect of ASA on the small intestine in experimental animals. We examined the ulcerogenic effects of plain and EC ASA on the gastrointestinal (GI) mucosa in cats: i.e., 1) the effect of feeding (fasted vs fed) on ASA-induced GI lesions; 2) the effects of cimetidine and misoprostol on ASA-induced GI lesions; and 3) the ulcerogenic effect of EC ASA on the GI mucosa. METHODS: Adult cats were used (4 to 6 animals per group). In the fed group, either plain ASA (20 mg/kg) or 1 EC ASA tablet (containing 100 mg ASA) was administered p.o. once daily after the morning meal for 3 days, whereas in the fasted group, ASA was given in the morning after an overnight fast. The animals were sacrificed 24 h after the final ASA dose and mucosal lesions in the GI tract were examined. Both cimetidine and misoprostol were administered p.o. 30 min before the morning meal. RESULTS: (1) In the fasted condition, ASA caused lesions in the corpus, antrum, duodenum and small intestine; the mean lesion area (MLA) was 0.25±0.1 cm2, 0.04±0.01 cm2, 0.24±0.1 cm2 and 0.11±0.05 cm2, respectively. When ASA was given after feeding, the duodenal lesions were markedly increased; the MLA was 0.75±0.31 cm2 (P<0.05 vs. fasted). (2) Both cimetidine (20 mg/kg, p.o.) and misoprostol (3 μg/kg, p.o.) markedly inhibited lesion formation in the stomach, but they did not affect duodenal lesions. Furthermore, cimetidine significantly (P<0.01) increased the area of lesions in the small intestine; the MLAs were 0.93±0.14 cm2 (cimetidine) and 0.13±0.05 cm2 (vehicle group). (3) EC ASA tablet (18.5-29.4 mg/kg) given orally once a day for 3 or 7 days did not cause any visible lesions in the stomach, but lesions were evident both in the duodenum and small intestine. The area of lesions increased with the duration of treatment; the MLAs following 7-day treatment were 0.98±0.13 cm2 (duodenum) and 1.58±0.82 cm2 (small intestine). CONCLUSIONS: 1) Adverse effects of ASA on the GI mucosa seemed to be decreased when ASA was given in the fasted condition. 2) ASA-induced duodenal lesions are resistant to cimetidine and misoprostol, suggesting that ASA caused the lesions by directly injuring the mucosa. 3) Histamine H2-receptor antagonists may aggravate small intestinal lesions caused by ASA. 4) Adverse effects of ASA on the stomach were markedly improved with EC ASA, but this treatment still caused lesions in the duodenum and small intestine, indicating that additional research is necessary to determine how to further reduce the toxicity of EC ASA." @default.
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• W935590972 date "2012-05-01" @default.
• W935590972 modified "2023-09-28" @default.
• W935590972 title "Su176 Ulcerogenic Effects of Plain and Enteric-Coated Aspirin on the Gastrointestinal Mucosa in Cats" @default.
• W935590972 doi "https://doi.org/10.1016/s0016-5085(12)61901-5" @default.
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