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- W93567462 abstract "Molecular species analyses have revealed that in most mammalian cells the 1-stearoyl 2-arachidonoyl species of phosphatidylinositol predominates greatly over other species and this may be significant in the functioning of this phospholipid. Tracer studies conducted in vivo and enzyme studies have suggested the importance of deacylation-reacylation reactions for the formation of the 1-stearoyl 2-arachidonoyl species and the enrichment of phosphatidylinositol with arachidonic acid via acylCoA: acyl-sn-glycero-(3)phosphoinositol acyltransferase activity. Our laboratory has also been interested in the influence of nutritional status on the physiological levels of myo-inositol and phosphatidylinositol in health and disease and on the fatty acid composition of phosphatidylinositol since such dietary-induced alterations could modify its cellular functioning. Inositol-deficient diets have been shown to produce a reduction in phosphatidylinositol levels and a marked accumulation of hepatic triglyceride in several animal species. The consumption of certain types of dietary fatty acids (e.g., fish oils containing eicosapentaenoic acid) produces a lowering of the arachidonoyl phosphatidylinositol in human platelets and provides for the introduction of novel molecular species (eicosapentaenoyl phosphatidylinositol) which may be related to the accompanying reduced platelet aggregation." @default.
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- W93567462 date "1985-01-01" @default.
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- W93567462 title "Nutritional Regulation of the Composition, Metabolism, and Function of Cellular Phosphatidylinositol" @default.
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