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- W93619610 abstract "Purpose: The cerebellum is involved in a wide number of integrative functions, but its role in pain experience and in the nociceptive information processing is poorly understood. In healthy volunteers we evaluated the effects of transcranial cerebellar direct current stimulation (tcDCS) by studyin g the changes in the perceptive threshold, pain intensity at given stimulation intensities (VAS:0-10) and laser evoked potentials (LEPs) variables (N1 and N2/P2 amplitudes and latencies). Methods: Fifteen subjects were studied before and after anodal, cathodal and sham tcDCS. LEPs were obtained using a neodymium:yttrium–aluminium–perovskite (Nd:YAP) laser and recorded from the dorsum of the left hand. VAS was evaluated by delivering laser pulses at two different intensities, respectively two and three times the perceptive threshold. Results: Cathodal polarization dampened significantly the perceptive threshold and increased the VAS score, while the anodal one had opposite effects. Cathodal tcDCS increased significantly the N1 and N2/P2 amplitudes and decreased their latencies, whereas anodal tcDCS elicited opposite effects. Motor thresholds assessed through transcranial magnetic stimulation were not affected by cerebellar stimulation. Conclusions: tcDCS modulates pain perception and its cortical correlates. Since it is effective on both N1 and N2/P2 components, we speculate that the cerebellum engagement in pain processing modulates the activity of both somatosensory and cingulate cortices. Present findings prompt investigation of the cerebellar direct current polarization as a possible novel and safe therapeutic tool in chronic pain patients." @default.
- W93619610 created "2016-06-24" @default.
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- W93619610 date "2015-10-05" @default.
- W93619610 modified "2023-10-10" @default.
- W93619610 title "Cerebellar direct current stimulation modulates pain perception in humans" @default.
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- W93619610 doi "https://doi.org/10.3233/rnn-140453" @default.
- W93619610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25777683" @default.
- W93619610 hasPublicationYear "2015" @default.