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- W93647679 abstract "Currently, there are two drugs on the market, gabapentin (Neurontin) and pregabalin (Lyrica), that are proposed to exert their therapeutic effect through binding to the alpha2-delta subunit of voltage-sensitive calcium channels. This activity was unexpected, as the alpha2-delta subunit had previously been considered not to be a pharmacological target. In this review, the role of the alpha2-delta subunits is discussed and the mechanism of action of the alpha2-delta ligands in vitro and in vivo is summarized. Finally, new insights into the mechanism of drugs that bind to this protein are discussed." @default.
- W93647679 created "2016-06-24" @default.
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- W93647679 date "2010-07-01" @default.
- W93647679 modified "2023-09-23" @default.
- W93647679 title "The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target." @default.
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