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- W936700375 abstract "Some modern pharmaceutical products with applications in the treatment of the skin disease are based on the use of the polymeric matrix as support for the medical drugs. The advantage of such products is the possibility to apply the active substance only in the desired area of the skin, the prolonged time contact between the product and the tissue and the possibility to control the delivery rate of the active substance [1–3]. Poly(ethylene oxide) (PEO) is one of the polymers used actually for this purpose. It is characterized by a great affinity for water and the capacity to produce gel in aqueous solutions [4, 5]. The spreading capacity and the possibility to remove the polymeric matrix from the skin after use are important properties of these products, directly correlated with the viscosity. The viscosity represents the friction force between two adjacent layers of flow and it is determined by the attractive forces acting between the particles of the fluid [6]. For the polymeric systems the viscosity is determined by the temporary or permanent junctions between the polymeric chains. These connections reduce the free motions of the macromolecules, and their stability is determined by the polymeric concentration, temperature and the rate of mechanical solicitation exerted on the sample. On the macroscopic scale these effects are reflected by the dependence of the viscosity on the temperature, concentration, and shear rate. There are many mathematical models, Binghman, Casson and power law, describing one or other of this dependence, applied to simple liquids or particularly system, but a general model, valid for a large category of samples, is very difficult to establish [6, 7]. Usually for a given sam-" @default.
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- W936700375 date "2011-06-01" @default.
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- W936700375 title "Algorithm for Preliminary Analysis of Viscosity Behaviour of Some Aqueous Poly(ethylene oxide) Gels" @default.
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- W936700375 doi "https://doi.org/10.12693/aphyspola.119.880" @default.
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