FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W93695276> ?p ?o ?g. }

• W93695276 endingPage "57" @default.
• W93695276 startingPage "149" @default.
• W93695276 abstract "Locally advanced rectal adenocarcinoma is typically treated with neoadjuvant chemoradiotherapy and surgery. We assessed the effect of an additional cycle of capecitabine/oxaliplatin chemotherapy before surgery in 57 patients with T3/4, N+/- or T1/2, N+ rectal cancer. MATERIALS AND STUDY DESIGN: Radiotherapy (total dose, 50.4 Gy) was combined with three cycles of chemotherapy (two cycles concomitant with radiotherapy), and each cycle consisted of oxaliplatin (130 mg/m2 on day 1) and capecitabine (825 mg/m2, twice per day from day 1 to day 14) for 21 days. In addition to assessing the safety of this treatment, the primary endpoint was pathological complete response (pCR). The secondary endpoint was the change in primary tumor and node stage from pre-treatment to post-surgery.Eleven patients (19%) experienced complete tumor regression and 23 patients (40%) experienced tumor regression grade 3. Tumor down-staging occurred in 31 patients (54.4%) and down-staging of nodes occurred in 25 patients (43.9%). There was a significant difference in tumor stage between pre-treatment and post-surgery (P <0.001). Patients with less advanced N stages had significantly better recurrence-free survival but similar metastasis-free survival and overall survival. Tumor regression grade was not associated with overall survival, recurrence-free survival or metastasis-free survival. The most common adverse events were pulmonary infection (n = 6, 10.5%) and intestinal obstruction (n = 6, 10.5%): CONCLUSIONS. An additional cycle of chemotherapy given after chemoradiotherapy and before surgery provided good efficacy and had a satisfactory safety profile in patients with locally advanced rectal cancer." @default.
• W93695276 created "2016-06-24" @default.
• W93695276 creator A5000497700 @default.
• W93695276 creator A5001432963 @default.
• W93695276 creator A5009738970 @default.
• W93695276 creator A5016800826 @default.
• W93695276 creator A5029132687 @default.
• W93695276 creator A5031913917 @default.
• W93695276 creator A5051100024 @default.
• W93695276 creator A5064560719 @default.
• W93695276 creator A5088016802 @default.
• W93695276 date "2014-05-24" @default.
• W93695276 modified "2023-09-27" @default.
• W93695276 title "Pilot study of intense neoadjuvant chemoradiotherapy for locally advanced rectal cancer: retrospective review of a phase II study." @default.
• W93695276 cites W1968620853 @default.
• W93695276 cites W1971049983 @default.
• W93695276 cites W1979238043 @default.
• W93695276 cites W1990330436 @default.
• W93695276 cites W2007296899 @default.
• W93695276 cites W2022848495 @default.
• W93695276 cites W2030914057 @default.
• W93695276 cites W2042189302 @default.
• W93695276 cites W2064357408 @default.
• W93695276 cites W2069825238 @default.
• W93695276 cites W2085919579 @default.
• W93695276 cites W2102886345 @default.
• W93695276 cites W2104089196 @default.
• W93695276 cites W2115153468 @default.
• W93695276 cites W2123377696 @default.
• W93695276 cites W2124695217 @default.
• W93695276 cites W2126532376 @default.
• W93695276 cites W2129408765 @default.
• W93695276 cites W2131421995 @default.
• W93695276 cites W2140626944 @default.
• W93695276 cites W2143769865 @default.
• W93695276 cites W2146161922 @default.
• W93695276 cites W2155611516 @default.
• W93695276 cites W2158318739 @default.
• W93695276 cites W2160152508 @default.
• W93695276 cites W76777577 @default.
• W93695276 doi "https://doi.org/10.1700/1491.16399" @default.
• W93695276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24852858" @default.
• W93695276 hasPublicationYear "2014" @default.
• W93695276 type Work @default.
• W93695276 sameAs 93695276 @default.
• W93695276 citedByCount "6" @default.
• W93695276 countsByYear W936952762015 @default.
• W93695276 countsByYear W936952762016 @default.
• W93695276 countsByYear W936952762019 @default.
• W93695276 countsByYear W936952762022 @default.
• W93695276 crossrefType "journal-article" @default.
• W93695276 hasAuthorship W93695276A5000497700 @default.
• W93695276 hasAuthorship W93695276A5001432963 @default.
• W93695276 hasAuthorship W93695276A5009738970 @default.
• W93695276 hasAuthorship W93695276A5016800826 @default.
• W93695276 hasAuthorship W93695276A5029132687 @default.
• W93695276 hasAuthorship W93695276A5031913917 @default.
• W93695276 hasAuthorship W93695276A5051100024 @default.
• W93695276 hasAuthorship W93695276A5064560719 @default.
• W93695276 hasAuthorship W93695276A5088016802 @default.
• W93695276 hasConcept C121608353 @default.
• W93695276 hasConcept C126322002 @default.
• W93695276 hasConcept C141071460 @default.
• W93695276 hasConcept C143998085 @default.
• W93695276 hasConcept C203092338 @default.
• W93695276 hasConcept C2776694085 @default.
• W93695276 hasConcept C2777909004 @default.
• W93695276 hasConcept C2778424827 @default.
• W93695276 hasConcept C2779013556 @default.
• W93695276 hasConcept C2779384505 @default.
• W93695276 hasConcept C2780283643 @default.
• W93695276 hasConcept C2780962732 @default.
• W93695276 hasConcept C509974204 @default.
• W93695276 hasConcept C526805850 @default.
• W93695276 hasConcept C535046627 @default.
• W93695276 hasConcept C71924100 @default.
• W93695276 hasConceptScore W93695276C121608353 @default.
• W93695276 hasConceptScore W93695276C126322002 @default.
• W93695276 hasConceptScore W93695276C141071460 @default.
• W93695276 hasConceptScore W93695276C143998085 @default.
• W93695276 hasConceptScore W93695276C203092338 @default.
• W93695276 hasConceptScore W93695276C2776694085 @default.
• W93695276 hasConceptScore W93695276C2777909004 @default.
• W93695276 hasConceptScore W93695276C2778424827 @default.
• W93695276 hasConceptScore W93695276C2779013556 @default.
• W93695276 hasConceptScore W93695276C2779384505 @default.
• W93695276 hasConceptScore W93695276C2780283643 @default.
• W93695276 hasConceptScore W93695276C2780962732 @default.
• W93695276 hasConceptScore W93695276C509974204 @default.
• W93695276 hasConceptScore W93695276C526805850 @default.
• W93695276 hasConceptScore W93695276C535046627 @default.
• W93695276 hasConceptScore W93695276C71924100 @default.
• W93695276 hasIssue "2" @default.
• W93695276 hasLocation W936952761 @default.
• W93695276 hasOpenAccess W93695276 @default.
• W93695276 hasPrimaryLocation W936952761 @default.
• W93695276 hasRelatedWork W1953161284 @default.
• W93695276 hasRelatedWork W1992982990 @default.

• next