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- W936981920 abstract "目的 测定异丙酚麻醉期间瑞芬太尼抑制病人气管插管和切皮时心血管反应的效应室靶浓度(EC50和EC95).方法 择期全麻手术病人60例,ASAⅠ或Ⅱ级,年龄20～65岁,体重40～75kg,随机分为6组(n=10):瑞芬太尼靶控输注(TCI),血浆靶浓度分别为1、2、3、4、5、6 ng/ml;异丙酚TCI,效应室靶浓度均为4.0 μg/ml.病人意识消失后静脉注射维库溴铵0.15 mg/kg,气管插管.插管后2min暂停瑞芬太尼TCI,切皮前10 min再以诱导时相同浓度瑞芬太尼TCI.记录入室安静时(基础值)、诱导后最低、插管后2 min内最高、切皮前1 min、切皮后2 min内最高的平均动脉压(MAP)和心率(HR).MAP和HR诱导后最低值与插管后2 min内最高值、切皮前1 min与切皮后2 min内最高值比较升高＞15%为心血管阳性反应.采用Probit法计算瑞芬太尼EC50和EC95.结果 瑞芬太尼抑制气管插管时心血管反应的EC50为4.41 ng/ml,95%可信区间(95%CI)为3.97～5.05 ng/ml;相应的EC95为6.42 ng/ml,95%CI为5.54～8.09 ng/ml.瑞芬太尼抑制切皮时心血管反应的EC50为2.05 ng/ml,95%CI为1.36～2.59 ng/ml;相应的EC95为3.89 ng/ml,95%CI为3.20～5.71 ng/ml.结论 异丙酚效应室靶浓度为4.0 μg/ml时,靶控输注瑞芬太尼抑制病人对气管插管和切皮诱发的心血管反应呈剂量依赖性,其效应室EC50分别为4.41 ng/ml和2.05 ng/ml。" @default.
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- W936981920 date "2007-01-20" @default.
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- W936981920 title "Effect-site concentration of remifentanil blunting cardiovascular responses to tracheal intubation and skin incision during propofol anesthesia" @default.
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