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- W937408876 abstract "目的探讨海藻酸钙／纳米羟基磷灰石／胶原复合材料植入动物体内的成骨能力。方法用18只3月龄健康新西兰大白兔制备兔桡骨中段15mm骨缺损模型。将每只兔子的左右前肢按随机数字表法分为实验组和对照组。在实验组兔桡骨缺损部位植入海藻酸钙／纳米羟基磷灰石／胶原复合材料，对照组为空白对照，骨缺损部位不植入任何材料。分别于术后4、8、12周采用X线和组织学方法检测缺损部位的成骨情况。结果18只模型兔均进入结果分析。X线结果显示，4周时实验组桡骨缺损区可见明显的骨生成影像，呈云雾状分布，随时间的延长骨量增多，至12周时，植人体已与缺损处断端骨性愈合，皮质骨连续性较好。对照组12周时显示骨断端骨质硬化，骨缺损区尚未修复。组织学结果表明，4周时实验材料内部可见骨形成细胞集中，随时间的延长骨量增多，并相互连接成片，到12周时，材料内骨小梁成熟，网孔间新生骨小梁相互连接成板状。结论海藻酸钙／纳米羟基磷灰石／胶原复合材料具有良好的成骨能力。" @default.
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- W937408876 date "2009-08-30" @default.
- W937408876 modified "2023-09-23" @default.
- W937408876 title "海藻酸钙/纳米羟基磷灰石/胶原复合材料修复兔桡骨缺损" @default.
- W937408876 doi "https://doi.org/10.3881/j.issn.1000-503x.2009.04.015" @default.
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