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- W937461909 abstract "The purpose of the present study was to determine whether there is the relation between the virulence of used HSV-1 strains and inhibition of apoptosis. HEp-2 cells were induced to apoptosis by osmotic shock after infection by HSV-1 strains. HSV-1 ts, earlier described as less virulent for mice inhibited apoptosis in smaller degree than native strain and HSV-1 tr. We suggest that this is due to the hyperproduction of IFN alpha by human cells after the stimulation by this strain. All strains of HSV-1 didn't inhibit apoptosis in the presence of IFN alpha and apoptosis was inhibited by anti IFN alpha antibodies. We confirm that IFN alpha plays an important function in controlling acute HSV-1 infection." @default.
- W937461909 created "2016-06-24" @default.
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- W937461909 date "2003-01-01" @default.
- W937461909 modified "2023-09-23" @default.
- W937461909 title "Differences in inhibition of apoptosis depending on the virulence of used herpes simplex virus type 1 strains. Function of interferon alpha in apoptotic death of virus infected cells." @default.
- W937461909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14743979" @default.
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