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- W937577164 abstract "The single dose pharmacokinetics of Isoniazid(7.5 mg/kg) and Rifampicin (12 mg/kg) wereexamined in 18 patients with mild or moderaterenal failure and 17 patients with severe renalfailure. The findings were compared with those in16 healthy subjects. The renal excretion ofIsoniazid and Acetyl Isoniazid and that ofRifampicin and Desacetyl Rifampicin wassignificantly less in patients with renal failure thanin healthy subjects. The decrease was greater inpatients with severe renal failure than in thosewith mild or moderate failure. The exposure(AUC) and half-life of Isoniazid calculated on thebasis of plasm concentrations were significantlyhigher in slow acetylators in both groups ofpatients than in healthy subjects. The differencesbetween the two groups of patients were,however, not significant. The plasma Isoniazidconcentrations among rapid acetylators and theRifampicin concentrations were similar in thethree groups of subjects, leading to similarexposure and half-life values. These findingssuggest that while it is not necessary to reduce thedosage of Isonizaid or that of Rifampicin in rapidacetylators, it is necessary to reduce Isoniaziddose in slow acetylators with renal failure." @default.
- W937577164 created "2016-06-24" @default.
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- W937577164 date "1991-01-01" @default.
- W937577164 modified "2023-09-26" @default.
- W937577164 title "Pharmacokinetics of isoniazid and rifampicin in patients with chronic renal failure" @default.
- W937577164 hasPublicationYear "1991" @default.
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