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- W938229049 abstract "After tuberculosis and leprosy, Buruli ulcer disease (BUD) is the third most common mycobacterial disease among immunocompetent people in the tropical world. BUD caused by Mycobacterium ulcerans, is characterized by indolent, necrotizing ulcerations of the skin. M. ulcerans disrupts macrophages and adipose cell monolayers in vitro, in lieu of growing within these cells. One of the major goals of the WHO's Global Buruli Ulcer Initiative is to develop new diagnostic tests to identify patients infected with M. ulcerans prior to the development of advanced ulcerative disease. Because M. ulcerans is infrequently isolated, every well-characterized clinical isolate has the potential to add to the understanding of the molecular epidemiology of M. ulcerans. The main histopathologic feature during the nodule stage is the necrosis of the subcutaneous adipose tissues. Necrosis can be classified as coagulative since the tissue appears to maintain its architecture and shows intense eosinophilia due to loss of the normal basophilia imparted by cytoplasmic RNA. Surgery is the current recommended treatment for all stages of BUD. Ulcerative lesions require wide debridement followed by skin grafting, techniques requiring referral to specialized health care facilities. Currently, international efforts directed by the WHO Buruli Ulcer Initiative are targeted towards defining the worldwide burden of this disease, the source(s) and route(s) of transmission, improved diagnostic assays, the mechanisms of pathogenesis, less invasive treatment options, and improved public health control strategies." @default.
- W938229049 created "2016-06-24" @default.
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- W938229049 date "2014-04-30" @default.
- W938229049 modified "2023-09-23" @default.
- W938229049 title "Mycobacterium ulcerans Infection and Buruli Ulcer Disease: Emergence of a Public Health Dilemma" @default.
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- W938229049 doi "https://doi.org/10.1128/9781555816988.ch9" @default.
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