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- W938330217 abstract "Abstract CXC chemokine receptor 3 (CXCR3) plays a critical role in recruitment of neutrophils, natural killer cells and T cells to sites of inflammation. Since these cell types are all critical in control of Toxoplasma gondii infection we hypothesized that CXCR3 is critical for immunity against T. gondii. To test this hypothesis we compared the course of T. gondii (ME49) infection in WT and CXCR3-/- mice on a C57BL/6 background. Following ME49 challenge, CXCR3-/- mice developed high brain parasite loads and succumbed to infection significantly faster than WT mice. T. gondii antigen-stimulated splenocytes from CXCR3-/- mice produced significantly more IFN-γ than WT splenocytes, but serum levels of this cytokine were lower in the former. Flow cytometry also revealed that CXCR3-/- mice recruit fewer leukocytes into the brain than WT mice early during infection. Finally, adoptive transfer studies involving Rag2-/- mice reconstituted with CXCR3-/- or WT lymphocytes revealed that CXCR3 expression on T cells was critical for effective immunity against ME49. Taken together, these results show that CXCR3 is critical for immunity against T. gondii. Furthermore, they suggest that increased susceptibility of CXCR3-/- mice is due to impaired leukocyte trafficking - most likely CXCR3 expressing T cells - into infection sites and not due to impairments in type I CD4+ T cell responses. Support: NIH" @default.
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- W938330217 date "2009-04-01" @default.
- W938330217 modified "2023-09-30" @default.
- W938330217 title "The chemokine receptor CXCR3 is required for optimal murine resistance against <i>Toxoplasma gondii</i> (129.30)" @default.
- W938330217 doi "https://doi.org/10.4049/jimmunol.182.supp.129.30" @default.
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