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- W93834546 abstract "·s~lC?,Ctive method& for t,he-,determination of diphen~ydr;mtine in pharmaceutical grade sample an<Un dosag~ forms are described. The·titrimetiic method is J?ased o.n the. precipitation of the chloride content of the drug as :AgCiwj th, a known exces.q(si.nitrate ·and' b~ck titration Of ihe .residual silver nitrate with tlp.ocyanate using iron (ill) as indicator. The reaction, stol.cbiometry and the ra!lge of determination have been eyaluated. The spectrophotof!!etric method involves the displacem_ ent of thiocyanate of mercuric thiocyanate from the ionized chloride and the subsequent reaction of the liberated thiocyanate with iron(ll) to form the familiar red coioII'ed complex, Fe(SCN) 2 + which is measured spectro photometrically at 460 nm;. Jbe Beer' s·law is obeyed over the range 5-45 J.Lg mL1 of diph~nhydrarni ne HCl, the · molar ab sorptjvity and Sandell se1_1sitivi~y being 3.45 x 10 3 L moL' 1 cm- 1 and 84.5 ng cm- 2 , respectively at 460 nm. The reaction variables have been optimized. The methods have bee!J found to be very_ simple, cost-effective and reliable for three dosage formS coniaining diphenhydramine hydrochJoride. Diphenhydramine hydrochloride (DPH), 2-(diphenyl methoxy) N, N-dimethyl ethylamine hydrochloride, is a conventional antihistamine of the H1 type (receptor antagonist), which can block most of the reactions of histamine in the body. Like man¥ other antihista mines, it has pronounced sedative properties. It also has antiemetic, anticholinergic and local anaesthetic properties. Diphenhydramine is found in many pharmaceutical preparations, it is usually given orally but it has also been given in severe allergies by deep intramuscular or slow intravenous injection. It is used in cough mixtures, for the control of symptoms of parkinson's disease, for prevention and treatment of nausea and vomitting. It has also been given with methaqualone as a hypnotic and a 2% water miscible cream has been used for allergic dermatoses and bums 1 ." @default.
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- W93834546 title "Precipitation and complex formation reactions based titrimetric and spectrophotometric methods for the determination of diphenhydramine hydrochloride" @default.
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