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- W9385478 abstract "The vagal afferents regulating cough in anesthetized guinea pigs (GPs) are acid sensitive mechanoreceptors that are differentiated from airway/ lung C-fibers and rapidly adapting receptors (RARs) by their conduction velocity and insensitivity to capsaicin and changes in airway luminal pressure (J Physiol, v557, 543-558, 2004). We hypothesized that the 'cough receptors' would have unique patterns of termination in nTS. We found a location rostral and lateral to obex at which a combination of NMDA (AP-5) and nonNMDA (CNQX) glutamate receptor antagonists could be microinjected bilaterally at doses that nearly abolished coughing evoked by citric acid challenge (10±2 and 2±1 coughs in control and treated GPs, respectively; n=6-10) but was without effect on basal respiratory rate or tachypnea evoked by either iv. histamine (RAR-selective) or bradykinin (C-fiber selective). Microinjecting these drugs into adjacent nTS locations (1-2mm distal) had no effect on cough (n=12). Neural tracing studies confirmed the selective termination of the cough receptors in this nTS location. Unique patterns of CNS termination of these vagal afferents may facilitiate their selective regulation of airway reflexes." @default.
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- W9385478 date "2009-04-01" @default.
- W9385478 modified "2023-09-25" @default.
- W9385478 title "Central terminations of the afferent nerves regulating cough in guinea pigs" @default.
- W9385478 doi "https://doi.org/10.1096/fasebj.23.1_supplement.1011.1" @default.
- W9385478 hasPublicationYear "2009" @default.
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