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• W93885486 abstract "Research Article1 August 1986free access DNA helicase activity of SV40 large tumor antigen. H. Stahl H. Stahl Search for more papers by this author P. Dröge P. Dröge Search for more papers by this author R. Knippers R. Knippers Search for more papers by this author H. Stahl H. Stahl Search for more papers by this author P. Dröge P. Dröge Search for more papers by this author R. Knippers R. Knippers Search for more papers by this author Author Information H. Stahl, P. Dröge and R. Knippers The EMBO Journal (1986)5:1939-1944https://doi.org/10.1002/j.1460-2075.1986.tb04447.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Large tumor antigen (T antigen) was extracted from SV40-infected African Green Monkey cells and purified to homogeneity by immunoaffinity chromatography. The purified T antigen preparations unwind DNA duplices of greater than 120 bp in a reaction which is dependent on magnesium ions and ATP hydrolysis. Based on these and other properties of the reaction we classify this newly discovered enzymatic activity as a eukaryotic DNA helicase. The helicase and the known ATPase function of T antigen cosediment with the mono- or dimeric 4-6 S form of T antigen, but not with higher T antigen aggregates. The helicase activity seems to be an intrinsic function of SV40 T antigen. First, several different T antigen-specific monoclonal antibodies interfere with the DNA unwinding activity; monoclonals which are known to reduce the T antigen-specific ATPase most strongly inhibited the helicase reaction. Second, mutant T antigens with impaired ATPase function also showed a reduced DNA unwinding activity. Previous ArticleNext Article Volume 5Issue 81 August 1986In this issue RelatedDetailsLoading ..." @default.
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• W93885486 date "1986-08-01" @default.
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• W93885486 title "DNA helicase activity of SV40 large tumor antigen." @default.
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• W93885486 doi "https://doi.org/10.1002/j.1460-2075.1986.tb04447.x" @default.
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