Matches in SemOpenAlex for { <https://semopenalex.org/work/W93895089> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W93895089 endingPage "445" @default.
- W93895089 startingPage "433" @default.
- W93895089 abstract "To measure the cohesive tensile strength of human LASIK corneal wounds.Twenty-five human eye bank corneas from 13 donors that had LASIK were cut into 4-mm corneoscleral strips and dissected to expose the interface wound. Using a motorized pulling device, the force required to separate the wound was recorded. Intact and separated specimens were processed for light and electron microscopy. Five normal human eye bank corneas from 5 donors served as controls. A retrospective clinical study was done on 144 eyes that had LASIK flap-lift retreatments, providing clinical correlation.The mean tensile strength of the central and paracentral LASIK wounds showed minimal change in strength over time after surgery, averaging 2.4% (0.72 +/- 0.33 g/mm) of controls (30.06 +/- 2.93 g/mm). In contrast, the mean peak tensile strength of the flap wound margin gradually increased over time after surgery, reaching maximum values by 3.5 years when the average was 28.1% (8.46 +/- 4.56 g/mm) of controls. Histologic and ultrastructural correlative studies found that the plane of separation always occurred in the lamellar wound, which consisted of a hypocellular primitive stromal scar centrally and paracentrally and a hypercellular fibrotic stromal scar at the flap wound margin. The pathologic correlations demonstrated that the strongest wound margin scars had no epithelial cell ingrowth-the strongest typically being wider or more peripherally located. In contrast, the weakest wound margin scars had epithelial cell ingrowth. The clinical series demonstrated the ability to lift LASIK flaps without complications during retreatments up to 8.4 years after initial surgery, correlating well with the laboratory results.The human comeal stroma typically heals after LASIK in a limited and incomplete fashion; this results in a weak, central and paracentral hypocellular primitive stromal scar that averages 2.4% as strong as normal comeal stroma. Conversely, the LASIK flap wound margin heals by producing a 10-fold stronger, peripheral hypercellular fibrotic stromal scar that averages 28.1% as strong as normal comeal stromal, but displays marked variability." @default.
- W93895089 created "2016-06-24" @default.
- W93895089 creator A5028590343 @default.
- W93895089 creator A5049711354 @default.
- W93895089 creator A5055540084 @default.
- W93895089 creator A5057277785 @default.
- W93895089 creator A5063968197 @default.
- W93895089 creator A5083984022 @default.
- W93895089 date "2005-09-02" @default.
- W93895089 modified "2023-10-13" @default.
- W93895089 title "Cohesive Tensile Strength of Human LASIK Wounds With Histologic, Ultrastructural, and Clinical Correlations" @default.
- W93895089 cites W1553185566 @default.
- W93895089 cites W1592139285 @default.
- W93895089 cites W1969732940 @default.
- W93895089 cites W1985164803 @default.
- W93895089 cites W1990647403 @default.
- W93895089 cites W1995571003 @default.
- W93895089 cites W2007201268 @default.
- W93895089 cites W2009405363 @default.
- W93895089 cites W2032329083 @default.
- W93895089 cites W2040016239 @default.
- W93895089 cites W2111110541 @default.
- W93895089 cites W2113952071 @default.
- W93895089 cites W2126570506 @default.
- W93895089 cites W2158087645 @default.
- W93895089 cites W2172043646 @default.
- W93895089 cites W2605558323 @default.
- W93895089 doi "https://doi.org/10.3928/1081-597x-20050901-04" @default.
- W93895089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16209440" @default.
- W93895089 hasPublicationYear "2005" @default.
- W93895089 type Work @default.
- W93895089 sameAs 93895089 @default.
- W93895089 citedByCount "140" @default.
- W93895089 countsByYear W938950892012 @default.
- W93895089 countsByYear W938950892013 @default.
- W93895089 countsByYear W938950892014 @default.
- W93895089 countsByYear W938950892015 @default.
- W93895089 countsByYear W938950892016 @default.
- W93895089 countsByYear W938950892017 @default.
- W93895089 countsByYear W938950892018 @default.
- W93895089 countsByYear W938950892019 @default.
- W93895089 countsByYear W938950892020 @default.
- W93895089 countsByYear W938950892021 @default.
- W93895089 countsByYear W938950892022 @default.
- W93895089 countsByYear W938950892023 @default.
- W93895089 crossrefType "journal-article" @default.
- W93895089 hasAuthorship W93895089A5028590343 @default.
- W93895089 hasAuthorship W93895089A5049711354 @default.
- W93895089 hasAuthorship W93895089A5055540084 @default.
- W93895089 hasAuthorship W93895089A5057277785 @default.
- W93895089 hasAuthorship W93895089A5063968197 @default.
- W93895089 hasAuthorship W93895089A5083984022 @default.
- W93895089 hasConcept C112950240 @default.
- W93895089 hasConcept C118487528 @default.
- W93895089 hasConcept C141071460 @default.
- W93895089 hasConcept C142724271 @default.
- W93895089 hasConcept C16930146 @default.
- W93895089 hasConcept C191897082 @default.
- W93895089 hasConcept C192562407 @default.
- W93895089 hasConcept C2777642821 @default.
- W93895089 hasConcept C2778257484 @default.
- W93895089 hasConcept C2778609529 @default.
- W93895089 hasConcept C2780269544 @default.
- W93895089 hasConcept C2780350528 @default.
- W93895089 hasConcept C71924100 @default.
- W93895089 hasConceptScore W93895089C112950240 @default.
- W93895089 hasConceptScore W93895089C118487528 @default.
- W93895089 hasConceptScore W93895089C141071460 @default.
- W93895089 hasConceptScore W93895089C142724271 @default.
- W93895089 hasConceptScore W93895089C16930146 @default.
- W93895089 hasConceptScore W93895089C191897082 @default.
- W93895089 hasConceptScore W93895089C192562407 @default.
- W93895089 hasConceptScore W93895089C2777642821 @default.
- W93895089 hasConceptScore W93895089C2778257484 @default.
- W93895089 hasConceptScore W93895089C2778609529 @default.
- W93895089 hasConceptScore W93895089C2780269544 @default.
- W93895089 hasConceptScore W93895089C2780350528 @default.
- W93895089 hasConceptScore W93895089C71924100 @default.
- W93895089 hasIssue "5" @default.
- W93895089 hasLocation W938950891 @default.
- W93895089 hasLocation W938950892 @default.
- W93895089 hasOpenAccess W93895089 @default.
- W93895089 hasPrimaryLocation W938950891 @default.
- W93895089 hasRelatedWork W1550715352 @default.
- W93895089 hasRelatedWork W2085231185 @default.
- W93895089 hasRelatedWork W2258183267 @default.
- W93895089 hasRelatedWork W2369014049 @default.
- W93895089 hasRelatedWork W2377943536 @default.
- W93895089 hasRelatedWork W2384961604 @default.
- W93895089 hasRelatedWork W2920746230 @default.
- W93895089 hasRelatedWork W3030473242 @default.
- W93895089 hasRelatedWork W3031018346 @default.
- W93895089 hasRelatedWork W4211058915 @default.
- W93895089 hasVolume "21" @default.
- W93895089 isParatext "false" @default.
- W93895089 isRetracted "false" @default.
- W93895089 magId "93895089" @default.
- W93895089 workType "article" @default.