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- W939081374 abstract "Probucol [bis(3,5-di-tert-butyl-4-hydroxyphenylthio)propane] is a marketed cholesterol-lowering agent that has been shown to be a potent antioxidant. The antioxidant activity of probucol inhibits the formation of oxidatively modified low density lipoproteins (LDL) and reduces atherosclerosis in animals. The uniqueness of probucol is its association with LDL; about 70% of the plasma probucol resides in LDL particles. It has been hypothesized that such association directly protects LDL from oxidation inside the arterial wall. Similar to all chain-breaking antioxidants, probucol is oxidized, consumed, and depleted during oxidation. This chapter describes the in vivo metabolic pathway of probucol as it undergoes oxidation. Three major metabolites, spiroquinone, diphenoquinone, and bisphenol are discussed. Bisphenol is also an antioxidant, being oxidized to diphenoquinone when acting as such. Therefore, the antioxidant activity is continuously regenerated in vivo. The chapter describes the assay for the antioxidant activity of probucol in LDL and whole serum and the analytical procedures for the determination of probucol and probucol metabolites in serum. Determination of these metabolites in serum may provide insight as to the mode of action of probucol in inhibition of atherosclerosis." @default.
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- W939081374 date "1994-01-01" @default.
- W939081374 modified "2023-10-16" @default.
- W939081374 title "[51] Antioxidant activity and serum levels of probucol and probucal metabolites" @default.
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- W939081374 doi "https://doi.org/10.1016/0076-6879(94)34122-2" @default.
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