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• W939249341 abstract "NMDA receptor (NMDA-R) antagonists are extensively used as schizoph- renia models due to their ability to evoke positive and negative symptoms as well as cog- nitive deficits similar to those of the illness. Likewise, 5-HT 2A receptor agonists display hallucinogen actions resembling psychotic symptoms. Overall, these drugs are useful mo- dels of schizophrenia for the screening of new antipsychotic drugs. However, the cellular and network elements involved in these actions are poorly known. Data obtained by several groups in recent years indicate that the prefrontal cortex (PFC) and anatomically related areas play a major role in these actions. This paper summarizes data obtained by the authors supporting that a) NMDA-R antagonists (phencyclidine -PCP-, dizocilpine -MK-801-) and 5-HT 2A agonists (DOI) alter the function of PFC in a similar fashion, and b) antipsy- chotic drugs exert their therapeutic action, at least in part, by normalizing hyperactivity states in PFC. While the actions of NMDA-R antagonists may involve blockade of these receptors in PFC and subcortical areas, that of antipsychotic drugs, in particular atypical drugs like clozapine, appear to be mediated essentially by a local action in PFC. These re- sults help to better understand the neurobiological basis of the action of pharmacological models of schizophrenia and the mode of action of antipsychotic drugs." @default.
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• W939249341 date "2009-01-01" @default.
• W939249341 modified "2023-09-26" @default.
• W939249341 title "Role of prefrontal cortex in pharmacological models of schizophrenia and antipsychotic action" @default.
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• W939249341 hasPublicationYear "2009" @default.
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