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- W939723275 abstract "The advent of the novel superior immunosuppressive agent cyclosporin A (CsA) has allowed new organ transplantations to be successfully attempted, but its clinical use is limited by its nephrotoxicity. Although there is indisputable evidence that high doses of CsA can produce morphological changes in the proximal tubule, data supporting a direct effect of CsA on tubular cells leading to dysfunction are less compelling (Bennett 1985). However, enzymuria, considered as one of the earliest and most sensitive indices of tubular damage, has not been used in a conclusive way in most studies except in an experimental setting (Whiting et al. 1983). As in renal transplantation differentiation between graft rejection and CsA nephrotoxicity is difficult, the aim of this study was (1) to investigate the drug tubulotoxicity using urinary marker enzymes, after liver transplantation, in patients with originally intact kidneys, and (2) to relate these results to circulating CsA levels." @default.
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- W939723275 date "1988-01-01" @default.
- W939723275 modified "2023-09-23" @default.
- W939723275 title "The Relationships Between Plasma Cyclosporin Levels and Renal Tubulotoxicity Assessed by Enzymuria After Liver Transplantation" @default.
- W939723275 cites W101739355 @default.
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- W939723275 doi "https://doi.org/10.1007/978-3-642-73113-6_28" @default.
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