FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W939982907> ?p ?o ?g. }

• W939982907 endingPage "20" @default.
• W939982907 startingPage "9" @default.
• W939982907 abstract "Nanotechnology based drug delivery systems are anticipated to overcome the persistent challenges in oral protein and peptide administration, and lead to the development of long awaited non-invasive therapies. Herein, an advanced single-step aerosol flow reactor based technology was used to develop a multifunctional site specific dual protein-drug delivery nanosystem. For this purpose, mucoadhesive porous silicon (PSi) nanoparticles encapsulated into a pH-responsive polymeric nanomatrix was developed for advanced oral type 2 diabetes mellitus therapy with an antidiabetic peptide, glucagon like peptide-1 (GLP-1), and the enzyme inhibitor, dipeptidyl peptidase-4 (DPP4). Chitosan surface modification inherited the mucoadhesiveness to the nanosystem which led to enhanced cellular interactions and increased cellular compatibility. An advanced aerosol flow reactor technology was used to encapsulate the chitosan modified nanoparticles into an enteric polymeric nanomatrix. The pH-sensitive polymeric matrix simultaneously prevented the gastric degradation of the encapsulated peptide and also preserved the mucoadhesive functionality of the chitosan-modified PSi nanoparticles in the harsh stomach environment. The multidrug loaded nanosystem showed augmented intestinal permeability of GLP-1, evaluated in an in vitro cell-based intestinal epithelium model, attributed to the permeation enhancer effect of chitosan and inhibition of GLP-1 degradation by the DPP4 inhibitor. The applied technology resulted in the development of a dual-drug delivery nanosystem that synergizes the antidiabetic effect of the loaded peptide and the enzyme inhibitor, thereby indicating high clinical potential of the system and preparation technique." @default.
• W939982907 created "2016-06-24" @default.
• W939982907 creator A5001979314 @default.
• W939982907 creator A5004309474 @default.
• W939982907 creator A5024426748 @default.
• W939982907 creator A5025489241 @default.
• W939982907 creator A5035901179 @default.
• W939982907 creator A5039602629 @default.
• W939982907 creator A5041458969 @default.
• W939982907 creator A5057830141 @default.
• W939982907 creator A5071356523 @default.
• W939982907 creator A5075882111 @default.
• W939982907 date "2015-11-01" @default.
• W939982907 modified "2023-10-17" @default.
• W939982907 title "Multistage pH-responsive mucoadhesive nanocarriers prepared by aerosol flow reactor technology: A controlled dual protein-drug delivery system" @default.
• W939982907 cites W1730898405 @default.
• W939982907 cites W1963492706 @default.
• W939982907 cites W1965799612 @default.
• W939982907 cites W1971938094 @default.
• W939982907 cites W1974707788 @default.
• W939982907 cites W1975077715 @default.
• W939982907 cites W1995350290 @default.
• W939982907 cites W1996246992 @default.
• W939982907 cites W1998955917 @default.
• W939982907 cites W2009809742 @default.
• W939982907 cites W2010109642 @default.
• W939982907 cites W2014394854 @default.
• W939982907 cites W2014680165 @default.
• W939982907 cites W2015301858 @default.
• W939982907 cites W2018755507 @default.
• W939982907 cites W2020451302 @default.
• W939982907 cites W2022101780 @default.
• W939982907 cites W2037096236 @default.
• W939982907 cites W2043122843 @default.
• W939982907 cites W2043830367 @default.
• W939982907 cites W2054087282 @default.
• W939982907 cites W2060268772 @default.
• W939982907 cites W2066685510 @default.
• W939982907 cites W2070170852 @default.
• W939982907 cites W2075537424 @default.
• W939982907 cites W2081158283 @default.
• W939982907 cites W2081676858 @default.
• W939982907 cites W2084948079 @default.
• W939982907 cites W2087240044 @default.
• W939982907 cites W2087577205 @default.
• W939982907 cites W2094672113 @default.
• W939982907 cites W2095123752 @default.
• W939982907 cites W2101405557 @default.
• W939982907 cites W2102665547 @default.
• W939982907 cites W2105865453 @default.
• W939982907 cites W2107076497 @default.
• W939982907 cites W2124131536 @default.
• W939982907 cites W2141880555 @default.
• W939982907 cites W2143073331 @default.
• W939982907 cites W2146093964 @default.
• W939982907 cites W2154899729 @default.
• W939982907 cites W2156945612 @default.
• W939982907 cites W2157877216 @default.
• W939982907 cites W2159205789 @default.
• W939982907 cites W2162139246 @default.
• W939982907 cites W2166661335 @default.
• W939982907 cites W2321609820 @default.
• W939982907 cites W2324431764 @default.
• W939982907 cites W2325907056 @default.
• W939982907 doi "https://doi.org/10.1016/j.biomaterials.2015.07.045" @default.
• W939982907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26253804" @default.
• W939982907 hasPublicationYear "2015" @default.
• W939982907 type Work @default.
• W939982907 sameAs 939982907 @default.
• W939982907 citedByCount "70" @default.
• W939982907 countsByYear W9399829072015 @default.
• W939982907 countsByYear W9399829072016 @default.
• W939982907 countsByYear W9399829072017 @default.
• W939982907 countsByYear W9399829072018 @default.
• W939982907 countsByYear W9399829072019 @default.
• W939982907 countsByYear W9399829072020 @default.
• W939982907 countsByYear W9399829072021 @default.
• W939982907 countsByYear W9399829072022 @default.
• W939982907 countsByYear W9399829072023 @default.
• W939982907 crossrefType "journal-article" @default.
• W939982907 hasAuthorship W939982907A5001979314 @default.
• W939982907 hasAuthorship W939982907A5004309474 @default.
• W939982907 hasAuthorship W939982907A5024426748 @default.
• W939982907 hasAuthorship W939982907A5025489241 @default.
• W939982907 hasAuthorship W939982907A5035901179 @default.
• W939982907 hasAuthorship W939982907A5039602629 @default.
• W939982907 hasAuthorship W939982907A5041458969 @default.
• W939982907 hasAuthorship W939982907A5057830141 @default.
• W939982907 hasAuthorship W939982907A5071356523 @default.
• W939982907 hasAuthorship W939982907A5075882111 @default.
• W939982907 hasConcept C15083742 @default.
• W939982907 hasConcept C155672457 @default.
• W939982907 hasConcept C171250308 @default.
• W939982907 hasConcept C18150654 @default.
• W939982907 hasConcept C185592680 @default.
• W939982907 hasConcept C192562407 @default.
• W939982907 hasConcept C2779732960 @default.
• W939982907 hasConcept C2779820397 @default.

• next