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• W940842978 startingPage "517" @default.
• W940842978 abstract "Almost all biological macromolecules undergo some form of processing event subsequent to their biosynthesis. These processes such as cleaving, phosphorylation, acetylation, and methylation are obligatory events in the establishment of functional expression of these molecules. DNA is also a subject to post-replication modification. This chapter focuses on DNA methylation, its nature, distribution, analysis, specificity, and biological function. It also presents other DNA modifications known to occur among prokaryotes and eukaryotes. The two naturally occurring methylated bases found in DNA include (1) N6-methyladenine (MeAde) and 5-methylcytosine (MeCyt). The nature and extent of DNA methylation is measured by a variety of techniques. Quantitative determination of the level of methylation depends on the ability to affect the resolution of the normal and methylated forms and to have sufficient radioactivity or mass (for spectrophotometric analysis). The available methods are adequate for studying the nature and level of MeCyt and MeAde in most organisms. The higher level of methylation analysis includes the determination of the primary base-sequence in which it occurs. Strategies adopted to achieve this include identification of 5′ and 3′ nearest neighbors, analysis of pyrimidine and purine tracts, and direct sequencing of oligonucleotides or restriction nuclease fragments that contain methylated bases. The DNA methylases of prokaryotes and eukaryotes transfer methyl groups from donor S-adenosyl-L-methionine (AdoMet) to acceptor DNA. Depending on the enzyme, both double-stranded and single-stranded DNAs may be suitable substrates." @default.
• W940842978 created "2016-06-24" @default.
• W940842978 creator A5059725617 @default.
• W940842978 date "1981-01-01" @default.
• W940842978 modified "2023-10-15" @default.
• W940842978 title "25 DNA Methylation" @default.
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