Matches in SemOpenAlex for { <https://semopenalex.org/work/W941527131> ?p ?o ?g. }
- W941527131 endingPage "58" @default.
- W941527131 startingPage "45" @default.
- W941527131 abstract "This chapter discusses recent progress in the biochemistry of choline acetyltransferase (ACh). Ach, which is generally accepted as a neurotransmitter both at the peripheral and central cholinergic synapses is synthesized by the reversible transfer of acetyl groups from acetyl-CoA to choline catalyzed by the enzyme choline acetyltransferase (ChAT). In the recent years, great progress has been achieved in the purification of the ChAT. The progress is mainly due to improved techniques in column chromatography, fractionation techniques, affinity chromatography and in stabilizing the purified enzyme. Several laboratories have prepared enzyme preparations with specific activity higher than 20 pmollmin mg protein. Different molecular forms of ChAT exist both as charge isoenzymes and as aggregates. However, the presence of aggregates seems to be dependent upon experimental conditions. Various reaction mechanisms have been proposed for ChAT. Strong evidence has been presented that a histidine residue in the active site participates in the acetyl transfer reaction. Antibodies raised against bovine brain ChAT inactivate ChAT almost completely in immunoprecipitation experiments. The antibodies crossreact with several species those are important in terms of immunohistochemical localization of ChAT. However, the specificity of several of the antibody preparations is still questioned, although encouraging results have recently been obtained in preparing monospecific antibodies against bovine brain ChAT of high specific activity." @default.
- W941527131 created "2016-06-24" @default.
- W941527131 creator A5028311297 @default.
- W941527131 date "1979-01-01" @default.
- W941527131 modified "2023-09-23" @default.
- W941527131 title "Recent Progress in the Biochemistry of Choline Acetyltransferase" @default.
- W941527131 cites W1019890646 @default.
- W941527131 cites W1533886919 @default.
- W941527131 cites W1549849683 @default.
- W941527131 cites W1580540091 @default.
- W941527131 cites W1622099522 @default.
- W941527131 cites W1853026346 @default.
- W941527131 cites W1939037149 @default.
- W941527131 cites W1965666040 @default.
- W941527131 cites W1971215453 @default.
- W941527131 cites W1975254399 @default.
- W941527131 cites W1980970998 @default.
- W941527131 cites W1982873198 @default.
- W941527131 cites W1990235683 @default.
- W941527131 cites W1991193346 @default.
- W941527131 cites W1991911275 @default.
- W941527131 cites W1993713095 @default.
- W941527131 cites W1994943263 @default.
- W941527131 cites W2000068263 @default.
- W941527131 cites W2001617195 @default.
- W941527131 cites W2007978416 @default.
- W941527131 cites W2011201516 @default.
- W941527131 cites W2017806958 @default.
- W941527131 cites W2018683368 @default.
- W941527131 cites W2030365597 @default.
- W941527131 cites W2035684545 @default.
- W941527131 cites W2039112309 @default.
- W941527131 cites W2045799781 @default.
- W941527131 cites W2047560181 @default.
- W941527131 cites W2051839164 @default.
- W941527131 cites W2055160904 @default.
- W941527131 cites W2058168288 @default.
- W941527131 cites W2059000929 @default.
- W941527131 cites W2068458044 @default.
- W941527131 cites W2069636948 @default.
- W941527131 cites W2075332411 @default.
- W941527131 cites W2077136764 @default.
- W941527131 cites W2079931313 @default.
- W941527131 cites W2081660201 @default.
- W941527131 cites W2084685421 @default.
- W941527131 cites W2087777761 @default.
- W941527131 cites W2088104165 @default.
- W941527131 cites W2095873344 @default.
- W941527131 cites W2110445451 @default.
- W941527131 cites W2131990375 @default.
- W941527131 cites W2149122777 @default.
- W941527131 cites W2236626078 @default.
- W941527131 cites W2256900562 @default.
- W941527131 cites W2330366828 @default.
- W941527131 cites W2333574740 @default.
- W941527131 cites W2410680894 @default.
- W941527131 cites W2413050884 @default.
- W941527131 cites W2524948131 @default.
- W941527131 doi "https://doi.org/10.1016/s0079-6123(08)64620-8" @default.
- W941527131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/92798" @default.
- W941527131 hasPublicationYear "1979" @default.
- W941527131 type Work @default.
- W941527131 sameAs 941527131 @default.
- W941527131 citedByCount "12" @default.
- W941527131 countsByYear W9415271312020 @default.
- W941527131 crossrefType "book-chapter" @default.
- W941527131 hasAuthorship W941527131A5028311297 @default.
- W941527131 hasConcept C104317684 @default.
- W941527131 hasConcept C119157956 @default.
- W941527131 hasConcept C159654299 @default.
- W941527131 hasConcept C179247698 @default.
- W941527131 hasConcept C181199279 @default.
- W941527131 hasConcept C185592680 @default.
- W941527131 hasConcept C198399640 @default.
- W941527131 hasConcept C203014093 @default.
- W941527131 hasConcept C2775910092 @default.
- W941527131 hasConcept C2778460671 @default.
- W941527131 hasConcept C2779649592 @default.
- W941527131 hasConcept C2781123555 @default.
- W941527131 hasConcept C55493867 @default.
- W941527131 hasConcept C71829478 @default.
- W941527131 hasConcept C86803240 @default.
- W941527131 hasConcept C98274493 @default.
- W941527131 hasConceptScore W941527131C104317684 @default.
- W941527131 hasConceptScore W941527131C119157956 @default.
- W941527131 hasConceptScore W941527131C159654299 @default.
- W941527131 hasConceptScore W941527131C179247698 @default.
- W941527131 hasConceptScore W941527131C181199279 @default.
- W941527131 hasConceptScore W941527131C185592680 @default.
- W941527131 hasConceptScore W941527131C198399640 @default.
- W941527131 hasConceptScore W941527131C203014093 @default.
- W941527131 hasConceptScore W941527131C2775910092 @default.
- W941527131 hasConceptScore W941527131C2778460671 @default.
- W941527131 hasConceptScore W941527131C2779649592 @default.
- W941527131 hasConceptScore W941527131C2781123555 @default.
- W941527131 hasConceptScore W941527131C55493867 @default.
- W941527131 hasConceptScore W941527131C71829478 @default.
- W941527131 hasConceptScore W941527131C86803240 @default.