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• W941725810 abstract "Publisher Summary This chapter discusses the different antihypertensive agents and their therapeutic efficiency. The chapter also discusses their potential to have positive or at least neutral effects on other factors, such as serum lipids, glucose tolerance, or potassium excretion. Major developments include clinical reports on the effects of intravenous administration of renin inhibitors and reports of the orally active renin inhibitors in primate models. Molecular modeling has suggested cyclic conformational constraints that are compatible with in vitro renin inhibition. The identification of a putative angiotensin II receptor gene indicates progress toward the development of biochemical tools and molecular models that will facilitate the development of angiotensin II antagonists. Molecular biology techniques are being used to provide a more detailed analysis of the angiotensin converting enzyme (ACE). The importance of tissue ACE over plasma enzyme in the long-term regulation of blood pressure has been described and the presence of ACE in vascular tissue and its inhibition has been demonstrated in rats. A combination ACE inhibitor-p-blocker has been reported to lower diastolic blood pressure with efficacy equivalent to enalapril and similar renovascular effects. The α-1 adrenoceptor and α antagonists for the treatment of hypertension have been discussed in the chapter. Animal models for the detection of post-junctional α-2 selective antagonists have been developed. Flosequinan, a direct-acting vasodilator, is effective in essential hypertension as well as in severe congestive heart failure. Two adenosine receptor agonists, PD 117519 and SC 32796, are relatively selective for adenosine A1 vs. A2 receptors and lower blood pressure without tachycardia in several hypertensive animal models. A contractile peptide substance termed “endothelin” has been isolated from porcine aortic endothelial cells. Research on endothelin is progressing rapidly and opportunities for new antihypertensive drug discovery should become evident in the not too distant future." @default.
• W941725810 created "2016-06-24" @default.
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• W941725810 date "1989-01-01" @default.
• W941725810 modified "2023-09-25" @default.
• W941725810 title "Chapter 6. Antihypertensive Agents" @default.
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• W941725810 doi "https://doi.org/10.1016/s0065-7743(08)60528-x" @default.
• W941725810 hasPublicationYear "1989" @default.
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