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- W942165679 abstract "This study was aimed to investigate the molecular genetics basis of a novel allele HLA-A+2459 in Chinese population. DNA was extracted from whole blood by PEL-FREEZ DNA extraction kit. The amplification of HLA-A exons 2-4 of the proband was preformed by allele specific primer PCR and the amplified product was sequenced bidirectionally with primers. The sequencing results showed HLA-A alleles of the proband as A*1101 and the novel allele. The sequences of the novel allele have been submitted to GenBank(DQ313255, DQ313256, DQ313257). After Blast HLA analysis, the novel allele showed only one nucleotide differences with HLA-A*24020101 at nuclcotidc position 527 T to C in exon 3. This results in an amino acid changes from Val to Ala at codon 152. In conclusion, this allele is a novel one and has been officially named HLA-A*2459 by the WHO Nomenclature Committee." @default.
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- W942165679 date "2007-10-20" @default.
- W942165679 modified "2023-09-26" @default.
- W942165679 title "一例HLA-A新等位基因A*2459的测序分析" @default.
- W942165679 hasPublicationYear "2007" @default.
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