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- W942675400 abstract "Aim: To explore the relationship between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and coronary heart disease (CHD). Methods: A total of 208 patients with CHD and 500 normal controls were subjected to detect MTHFR C677T gene polymorphism using PCR-RFLP. Results: There were three kinds of genotype: C/C, C/T and T/T. In CHD group, the frequencies of C/C, C/T and T/T genotype were 15.4%, 45.7% and 38.9%, respectively. T and C allele frequencies were 61.8% and 38.2%, respectively. In the control group, the frequencies of C/C, C/T and T/T genotype were 35.6%, 44.0%, and 20.4%, respectively. T and C alleles frequencies were 42.4% and 57.6%. The frequencies of T/T genotype and T allele in CHD group were significantly higher than those in the control group (P＜0.05). Conclusion: There may be an association between MTHFR C677T polymorphism and CHD in Henan Han population." @default.
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- W942675400 date "2007-05-20" @default.
- W942675400 modified "2023-09-26" @default.
- W942675400 title "河南汉族冠心病患者N5,N10-亚甲基四氢叶酸还原酶基因C677T多态性检测" @default.
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