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- W94335222 abstract "Studies were made to determine whether the activation of the enzymic system that transforms tyrosine into biologically active orthoquinones is characteristic of animal tissue. White male rats and mice were given a whole- body dose of 1000 r Co/sup 60/ gamma radiation. At various intervals postirradiation (2, 4, 5, and 24 hours), the animals were decapitated; and the skin was removed. A homogenate of the skin was prepared in phosphate buffer and tyrosine solution and incubated at 37 deg . Tyrosinase activity was determined from the amount of orthoquinones formed. Results indicate that whole-body irradiation of rats and mice with a lethal dose leads to the activation of tyrosine in the skin during the first hours after irradiation. Maximum activation of skin tyrosinase in mice and rats was observed within 3 to 4 hours postirradiation followed by a slow fall during the first 24 hours. Due to the activation of tyrosinase, an increase of biologically active orthoquinones occurs in the skin of irradiated animals during the first hours after exposure. It is suggested that the resulting substances may be products of the adrenal system along with free tyrosine. (H.M.G.)" @default.
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- W94335222 date "1963-01-01" @default.
- W94335222 modified "2023-09-23" @default.
- W94335222 title "TYROSINASE ACTIVITY OF SKIN IN IRRADIATED MICE AND RATS" @default.
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