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- W943456250 abstract "Publisher Summary This chapter discusses the somatomedin (SM) levels in human beings. It compares the SM concentration in adults and older children with that reported by various authors in sera of hypophysectomized patients and in pituitary dwarfs. As each group has employed a separate serum standard, normalization of the standards is performed based on the mean potency of the normal groups, excluding young children, which has been considered to be 1 somatomedin unit per milliliter. When the apparent potency of the house standard is recalculated, the analytic values are corrected. The results show a remarkable agreement among the various authors. In the case of patients who had surgical removal of a normal pituitary, the discrimination from the SM activity of normal serum is excellent. The discrimination in the case of idiopathic pituitary dwarfism is somewhat less clear. In normal individuals the diurnal variation in SM concentration is not significant. When hypopituitary patients are treated with growth hormone (GH), there is a subsequent rise in SM. The chapter discusses the type of response achieved with 5 mg of hGH per day. After intramuscular injection, little rise is noted for 6–12 hours." @default.
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- W943456250 date "1975-01-01" @default.
- W943456250 modified "2023-09-26" @default.
- W943456250 title "Somatomedin Levels in Human Beings" @default.
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- W943456250 doi "https://doi.org/10.1016/b978-0-12-027308-9.50017-2" @default.
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