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- W94349977 abstract "Background: In patients with nonvalvular AF enrolled in ROCKET AF, rivaroxaban was noninferior to warfarin for prevention of stroke and systemic embolism and caused less intracranial hemorrhage (ICH) and fatal bleeding events. The prevalence of both AF and diabetes mellitus (DM) are rising, and the 2 commonly occur together, but the efficacy and safety of rivaroxaban in patients with DM and AF have not been described. Methods: We compared the efficacy and safety of rivaroxaban and warfarin in patients with (n=5635) and without (n=8508) DM enrolled in ROCKET AF. The primary efficacy outcome was the rate of stroke or systemic embolism; principal safety outcomes were the rates of major or non-major clinically relevant (NMCR) bleeding and hemorrhagic stroke. Results: In patients with DM randomized to rivaroxaban vs warfarin, rates of primary events (1.59 vs 2.15/100 pt-yrs) were similar to those in patients without DM (1.77 vs 2.16/100 pt-yrs; interaction p=0.60; Figure), and the same was true for rates of is..." @default.
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- W94349977 date "2012-11-20" @default.
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- W94349977 title "Abstract 15544: Rivaroxaban Compared with Warfarin in Patients with Atrial Fibrillation and Diabetes: A Subgroup Analysis of the ROCKET AF Trial" @default.
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