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- W943544897 abstract "Response surface methodology and central composite design, statistical tools for optimization of process variables, were used to optimize various factors, viz., carbon/nitrogen ratio, pH, and temperature, governing recovery of destruxin from the culture filtrate of Metarhizium anisopliae. A second-order polynomial equation was determined by multiple regression analysis of the experimental data. The critical optimized conditions for destruxin A recovery were CN ratio, 3.48; pH, 7.01; and temperature, 25.18 °C and for destruxin E were CN ratio, 3.46; pH, 6.99; and temperature, 25.14 °C. At these optimized culture conditions, the effect of destruxin biosynthesis precursors on the recovery of destruxin A and E was investigated. The supplementation of the culture medium with 0.02 % β-alanine resulted in maximum increment in destruxin A and E recovery. The effect of these supplements on augmenting the activity of esterase, acid phosphatase, and alkaline phosphatase was concomitant with heightening in the production of destruxin." @default.
- W943544897 created "2016-06-24" @default.
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- W943544897 date "2015-01-01" @default.
- W943544897 modified "2023-09-23" @default.
- W943544897 title "Optimization of the Cyclodepsipeptidic Destruxin Recovery from Broth Culture of Metarhizium anisopliae and Its Augmentation by Precursor Supplementation" @default.
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- W943544897 doi "https://doi.org/10.1007/978-3-319-14499-3_9" @default.
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