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- W943552968 abstract "This chapter focuses on the regulation of prolactin (Prl) synthesis, and more specifically the possible interrelationships between estrogen and other regulatory factors. Prl is a polypeptide hormone produced in the anterior pituitary gland of most vertebrates by a specialized population of cells termed lactotrophs or mammotrophs. Prl, growth hormone, and chorionic somatomammotropin are related protein hormones coded from structurally similar genes which appear to have evolved from a common precursor. The molecular structure of the Prl gene domain is also presented. The effects of estrogen on Prl synthesis and the regulation of Prl gene transcription are also emphasized. The estrogen stimulates the transcription of the rat Prl gene in vivo through two independent mechanisms. One mechanism does not require synthesis of any intermediary protein by the anterior pituitary and appears to be mediated directly by the estrogen receptor. The second mechanism is mediated through a reduction in amount of dopamine reaching the cells of the anterior pituitary. The chapter discusses the regulation of Prl gene expression by factors other than estrogen. A number of possible mechanisms whereby estrogen might modulate this regulation by other factors are also illustrated." @default.
- W943552968 created "2016-06-24" @default.
- W943552968 creator A5057423261 @default.
- W943552968 creator A5069785361 @default.
- W943552968 date "1986-01-01" @default.
- W943552968 modified "2023-09-26" @default.
- W943552968 title "The Hormonal Regulation of Prolactin Gene Expression: An Examination of Mechanisms Controlling Prolactin Synthesis and the Possible Relationship of Estrogen to These Mechanisms" @default.
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