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- W943757772 abstract "目的：探讨骨髓间质干细胞对MPP^＋损伤的离体黑质-纹状体脑片多巴胺能神经元的保护作用。方法：建立MPP^＋损伤的离体脑片模型。取成年大鼠骨髓，培养、分离和纯化骨髓间质干细胞。将骨髓间质干细胞与离体脑片联合培养，通过免疫组化和电镜等方法观察骨髓间质干细胞对联合培养的MPP^＋损伤脑片的保护作用。结果：MPP^＋可造成离体黑质-纹状体脑片的细胞大量死亡，但与MSCs联合培养7d，脑片周围神经轴突生长增多，脑片中的细胞死亡减少、超微结构损伤减轻、表达TH阳性的细胞数目增多（P〈0．05）。结论：MSCs在体外能促进受损的黑质-纹状体脑片多巴胺能神经元存活，可望用于帕金森病的移植治疗。" @default.
- W943757772 created "2016-06-24" @default.
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- W943757772 date "2007-01-01" @default.
- W943757772 modified "2023-09-24" @default.
- W943757772 title "骨髓间质干细胞对MPP^＋损伤离体大鼠纹状体-黑质脑片的作用" @default.
- W943757772 hasPublicationYear "2007" @default.
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