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- W944280108 abstract "Chronic low-grade inflammation may contribute to vascular endothelial dysfunction with aging. Changes in the inflammatory properties of circulating mononuclear cells (MC) may be involved, but data are limited. Compared with young controls (Y, 25±2 yr, n=9), healthy older adults (O, 65±2 yr, n=12) had elevated plasma concentrations of C-reactive protein (0.85±0.15 vs. 0.42±0.10 mg/L, P<0.05) and interleukin-6 (IL-6, 1.32±0.22 vs. 0.64 ±0.05 pg/ml, P<0.05), and reduced maximal forearm blood flow responses to acetylcholine (12.8±1.3 vs. 17.9±2.2 mL tissue−1min−1, P<0.05). MC mRNA expression (real-time RT PCR) of inflammatory cytokines monocyte chemoattractant protein-1 (MCP-1, 1.52±0.34 vs. 0.00±0.42 Fold change from Y[FC], P<0.05), tumor necrosis factor α (TNF-α, 2.68±0.50 vs. 0.00±0.34 FC, P<0.05) and IL-6 (1.98±0.91 vs. 0.00±0.83 FC, P=0.07) were greater, whereas the anti-inflammatory nuclear transcription factor peroxisome proliferator activated receptor α (PPAR-α, −1.28±0.50 vs. 0.00±0.51 FC, P<0.05) was lower in O. MC protein expression (Western blot analysis) of inflammatory molecules MCP-1, TNF-α and IL-6 also was greater in a subgroup of O vs. Y. These preliminary results provide evidence that MC of healthy older adults exhibit a pro-inflammatory phenotype that may contribute to chronic low-grade systemic inflammation and vascular endothelial dysfunction with aging. NIH AG006537, AG013038, AG022241" @default.
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- W944280108 date "2008-03-01" @default.
- W944280108 modified "2023-09-26" @default.
- W944280108 title "Inflammatory Circulating Mononuclear Cell Phenotype in Healthy Older Adults with Low‐Grade Systemic Inflammation and Endothelial Dysfunction" @default.
- W944280108 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1155.4" @default.
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