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- W944284997 abstract "This chapter discusses the different cadherin subclasses as regulators of intercellular communication, and highlights the principal mechanisms of cadherin function in different cellular contexts. The vertebrate classical cadherins are typically single-span transmembrane proteins composed of five extracellular cadherin domains and a conserved cytoplasmic region. The hallmark of the cadherin family is calcium-dependent cell-to-cell binding between cadherin homo- or heterodimers. Classical cadherins are subdivided into two major subgroups, type I and type II cadherins, based on phylogenetic maps. Type I classical cadherins including E-, N-, P-, and R-cadherins generally mediate strong adhesive interactions. They are essential for the formation of the embryonic germ layers and assembly of organs. A characterizing feature of classical vertebrate and invertebrate cadherins is the association of their highly conserved cytoplasmic domains with the “amadillo repeat” family protein β-catenin. β-catenin serves multiple functions within cells and switches roles between the cadherin-associated state at the plasma membrane, the cytoplasmic state characterized by interactions affecting cell signaling events, and transcriptional activation in the nucleus upon Wnt-induced signaling. The largest subgroup of cadherin-related proteins, with about 70 members in vertebrates, are transmembrane protocadherins that are composed of six or seven extracellular cadherin domains and distinct cytoplasmic regions. Genomic organization subdivides protocadherins into clustered and non-clustered groups. The clustered protocadherins Pdchα, Pdchβ, and Pdchγ are generated from a small genome locus on human chromosome 5q31, and encode 52 cadherin-related molecules. The Pdchα and Pdchγ are transcribed from variable exons encoding different extracellular domains and a constant exon generating a conserved, cluster-specific carboxy terminal domain." @default.
- W944284997 created "2016-06-24" @default.
- W944284997 creator A5054639915 @default.
- W944284997 date "2010-01-01" @default.
- W944284997 modified "2023-09-25" @default.
- W944284997 title "Cadherin Regulation of Adhesive Interactions" @default.
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