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- W944335869 abstract "目的：研究复方五味子素B对结肠癌耐药细胞株THC-8307／OXA的逆转作用及其作用机制。方法：采用MTT比色法检测奥沙利铂（OXA）和复方五味子素B（3,SC）的细胞毒性；碱性磷酸酶免疫组织化学法和Westernblot检测γSC对THC-8307／OXA细胞MRPl蛋白水平的影响。结果：1sc（6．0，12．5，25mg·L^-1）对人结肠癌细胞（THC-8307）和耐奥沙利铂人结肠癌细胞（THC-8307／OXA）无显著毒性作用，OXA对THC-8307的IC50为0．06mg·L^-1，对THC-8307／OXA的IC50为2．32mg·L^-1，THC-8307／OXA较THC-8307对OXA耐药39倍，γSC（6．0，12．5，25mg·L^-1）能使OXA对THC．8307／OXA细胞的Ic。从2．32mg·L^-1依次下降至0．370，0．128，0．057mg·L^-1，逆转倍数分别为6．2，18．1，40．7倍。碱性磷酸酶免疫组织化学法和Westernblot检测γSC（12．5mg·L^-1）处理48h后，THC-8307／OXA细胞MRP1表达明显降低。结论：γSC具有逆转耐奥沙利铂人结肠癌细胞的MDR作用，其作用机制与下调MRP1表达有关。" @default.
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- W944335869 date "2010-01-01" @default.
- W944335869 modified "2023-09-23" @default.
- W944335869 title "复方五味子素B对人结肠癌耐奥沙利铂细胞株THC-8307／OXA的逆转作用及其机制的研究" @default.
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