FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W9448944> ?p ?o ?g. }

• W9448944 abstract "Introduction: The main aim was to investigate Dukes B cancerprognosis using array comparative genomic hybridisation (aCGH).The cancers were typed for microsatellite instability (MSI), APC lossof heterozygosity (LOH) and ploidy. A secondary aim was theselection, on the basis of aCGH results, of potential colorectal cancergenes using In Situ Hybridisation (ISH). Sporadic adenomas werealso investigated with aCGH to investigate the timing ofchromosomal instability in tumourigenesis.Methods: Dukes B cancers collected in Oxford, Leeds and Harrowwere examined using aCGH based on a set of 3452 BAC clones at~1Mb spacing. MSI was assessed using BAT26 and D5S346.D5S346 gave LOH at the APC gene locus. Ploidy was assessedusing flow cytometry (FACS). From the aCGH data genes in regionsof copy number gain were chosen for ISH analysis.Results: 79 Dukes B cancers (43 good outcome, 36 bad outcome onthe basis of 5 year survival) were investigated with aCGH. The mostcommonly gained chromosomes across all cancers were 13, 20 and7, and the most commonly lost were 22, 18 and 14. Comparingsurvival groups; chromosome 6 was more often lost in cancersassociated with good outcome, chromosome 16 was more oftengained in microsatellite stable cancers associated with goodoutcome, and chromosome 22 more often gained in microsatellitestable cancers associated with poor outcome. Chromosome 13showed greater than single copy number change significantly moreoften in bad outcome cancers. Several new areas of small genomicgain and loss were detected. Four candidate genes were identified(CDX2, RHOA, FLT1 and ARHGEF1). None showed a relationshipwith outcome. Large scale chromosomal changes were found in 10of14 sporadic adenomas. Conclusions: Array CGH did identify some difference between goodand bad outcome Dukes B cancers. However on the basis of thisdata, the technique could not be used as a useful clinical tool topredict prognosis." @default.
• W9448944 created "2016-06-24" @default.
• W9448944 creator A5013638031 @default.
• W9448944 date "2011-07-28" @default.
• W9448944 modified "2023-09-27" @default.
• W9448944 title "Dukes stage B colorectal cancers analysed with array comparative genomic hybridisation" @default.
• W9448944 cites W1438937135 @default.
• W9448944 cites W1483245334 @default.
• W9448944 cites W1488591768 @default.
• W9448944 cites W1499807572 @default.
• W9448944 cites W1500930737 @default.
• W9448944 cites W1511545125 @default.
• W9448944 cites W1514920509 @default.
• W9448944 cites W1533555842 @default.
• W9448944 cites W1544046482 @default.
• W9448944 cites W1544851750 @default.
• W9448944 cites W1554815317 @default.
• W9448944 cites W1556655356 @default.
• W9448944 cites W1558473757 @default.
• W9448944 cites W1561159867 @default.
• W9448944 cites W1562829802 @default.
• W9448944 cites W157821847 @default.
• W9448944 cites W1580962701 @default.
• W9448944 cites W1601779670 @default.
• W9448944 cites W1615389580 @default.
• W9448944 cites W1619256199 @default.
• W9448944 cites W1658127082 @default.
• W9448944 cites W1708473085 @default.
• W9448944 cites W1877472591 @default.
• W9448944 cites W1908327267 @default.
• W9448944 cites W1964715298 @default.
• W9448944 cites W1966109603 @default.
• W9448944 cites W1967137553 @default.
• W9448944 cites W1967398093 @default.
• W9448944 cites W1968046362 @default.
• W9448944 cites W1968101073 @default.
• W9448944 cites W1969561516 @default.
• W9448944 cites W1969649126 @default.
• W9448944 cites W1970980262 @default.
• W9448944 cites W1973677994 @default.
• W9448944 cites W1973800266 @default.
• W9448944 cites W1974554004 @default.
• W9448944 cites W1975403964 @default.
• W9448944 cites W1977284533 @default.
• W9448944 cites W1978020199 @default.
• W9448944 cites W1978896163 @default.
• W9448944 cites W1980062511 @default.
• W9448944 cites W1980847511 @default.
• W9448944 cites W1981411105 @default.
• W9448944 cites W1982533604 @default.
• W9448944 cites W1983354388 @default.
• W9448944 cites W1985035689 @default.
• W9448944 cites W1985253858 @default.
• W9448944 cites W1985723830 @default.
• W9448944 cites W1985793111 @default.
• W9448944 cites W1986865912 @default.
• W9448944 cites W1986971238 @default.
• W9448944 cites W1987016846 @default.
• W9448944 cites W1987107448 @default.
• W9448944 cites W1988242944 @default.
• W9448944 cites W1989215255 @default.
• W9448944 cites W1989653345 @default.
• W9448944 cites W1989685743 @default.
• W9448944 cites W1992595726 @default.
• W9448944 cites W1994359291 @default.
• W9448944 cites W1994700168 @default.
• W9448944 cites W1994922837 @default.
• W9448944 cites W1995469832 @default.
• W9448944 cites W1998028567 @default.
• W9448944 cites W1998170462 @default.
• W9448944 cites W1999935922 @default.
• W9448944 cites W2000362305 @default.
• W9448944 cites W2000452401 @default.
• W9448944 cites W2000478575 @default.
• W9448944 cites W2001258296 @default.
• W9448944 cites W2001272450 @default.
• W9448944 cites W2002404925 @default.
• W9448944 cites W2005088732 @default.
• W9448944 cites W2006239354 @default.
• W9448944 cites W2007717461 @default.
• W9448944 cites W2008398178 @default.
• W9448944 cites W2008773040 @default.
• W9448944 cites W2009205355 @default.
• W9448944 cites W2009973559 @default.
• W9448944 cites W2010005918 @default.
• W9448944 cites W2010875436 @default.
• W9448944 cites W2013268532 @default.
• W9448944 cites W2013743651 @default.
• W9448944 cites W2014495259 @default.
• W9448944 cites W2014571977 @default.
• W9448944 cites W2014995450 @default.
• W9448944 cites W2015550902 @default.
• W9448944 cites W2016462887 @default.
• W9448944 cites W2017602527 @default.
• W9448944 cites W2018077784 @default.
• W9448944 cites W2018218984 @default.
• W9448944 cites W2018884883 @default.
• W9448944 cites W2019330877 @default.
• W9448944 cites W2020320512 @default.
• W9448944 cites W2020437431 @default.

• next