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- W945150327 abstract "Publisher Summary This chapter discusses rodent longevity models in respect to the involvement of the growth hormone (GH)-insulin-like growth factor I (IGF-I)/insulin axis. Six of the eight models focused on here exhibit a reduction in plasma IGF-I or IGF-I signaling. Most of the models show a reduction in plasma insulin levels during the feeding cycle, although insulin sensitivity seems to be augmented. Some of the models are resistant to stresses except one model which is susceptible to oxidative stress. At present, one cannot determine whether the IGF-I or the insulin pathway or theft cross talk is more essential for life span regulation. However, if mammals have obtained multiple and more complex signal systems for sensing nutritional status and eliciting adaptive responses during evolution, it is reasonable that many signaling molecules and related pathways would be involved in the regulation of aging and life span in mammals. These models should provide insights into a role for the GH-IGF-I/insulin axis in brain aging and help in protective strategies against it." @default.
- W945150327 created "2016-06-24" @default.
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- W945150327 date "2006-01-01" @default.
- W945150327 modified "2023-09-24" @default.
- W945150327 title "Rodent Models for the Study of the Role of Growth Hormone–Insulin-like Growth Factor-I or the Insulin Axis in Aging and Longevity: Special Reference to a Transgenic Dwarf Rat Strain and Calorie Restriction" @default.
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- W945150327 doi "https://doi.org/10.1016/b978-012088484-1/50016-1" @default.
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