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- W94529567 abstract "Treatment failures with isotretinoin in female patients are frequently related to endocrinological dysfunctions. Such a concept has never been discussed in male patients.An extensive endocrinological work-up has been performed in nine male patients who presented with an acne refractory to conventional treatment and to isotretinoin. Adrenal dysfunction was found in four patients and isolated 5-alpha reductase hyperactivity in 2 cases. Three work-ups were normal. A suppressive treatment in three patients with adrenal dysfunction provided immediate efficacy.These results would provide insight into the mechanism of refractory acne in men." @default.
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- W94529567 date "1999-01-01" @default.
- W94529567 modified "2023-09-23" @default.
- W94529567 title "[Acne in the male resistant to isotretinoin and responsibility of androgens: 9 cases, therapeutic implications]." @default.
- W94529567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10095884" @default.
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