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- W945303785 abstract "This chapter discusses the measurement of cytochrome P450 activation of xenobiotics using the Ames salmonella test. The toxicity of many chemicals is because of their metabolic conversion to reactive electrophiles which interact irreversibly with critical nucleophilic sites on cellular macromolecules. In both laboratory animals and humans, the cytochrome P450 system has been shown to be the major enzyme system involved in the activation of most xenobiotics. It is generally accepted that for the vast majority of carcinogens, the initiation stage of carcinogenesis involves a critical activation step. This metabolic activation results in the formation of an electrophile capable of causing an inheritable alteration in the DNA of a cell. The popularity of the Ames test stems from the fact that it is (1) simple to perform, (2) relatively inexpensive, (3) very sensitive, and (4) able to detect both base-pair substitution and frameshift mutations." @default.
- W945303785 created "2016-06-24" @default.
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- W945303785 date "1991-01-01" @default.
- W945303785 modified "2023-09-24" @default.
- W945303785 title "[48] Measurement of cytochrome P450 activation of xenobiotics using the ames Salmonella test" @default.
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- W945303785 doi "https://doi.org/10.1016/0076-6879(91)06119-n" @default.
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