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- W94552537 abstract "Purpose Estradiol (E2) is neuroprotective, however the mechanisms involved remain unclear. Here we investigated the effects of E2 and its metabolites on cultured microglia and oligodendrocytes. Results Treatment with E2 differentially modulated growth of microglia (BV2) and oligodendrocytes (Oli-Neu). E2 significantly induced growth of Oli-Neu cells and inhibited growth of BV2 cells. In BV2 cells the inhibitory effects of E2 were mimicked by DPN (ER-β agonist), but not by PPT (ER-α agonist). Additionally, the anti-proliferative effects of E2 on BV2 cells were blocked by ICI (unspecific ER antagonist) but not by MPP (ER-α antagonist). These findings suggest that effects of E2 on BV2 growth are ER-β mediated. Interestingly, the inhibitory effects of E2 were mimicked by 2-methoxyestradiol (2ME) and 2-hydroxyestradiol, two endogenous E2 metabolites with no ER-affinity. Additionally, 2ME decreased LPS-stimulated iNOS and COX expression. Conclusions Our findings suggest that inhibitory effects of E2 on microglia would limit neuronal injury by decreasing cell growth and production of cytotoxic molecules, whereas pro-mitogenic effects of E2 on oligodendrocytes would promote neuronal recovery. Finally, the protective effects of E2 can be mediated via both ER-dependent and ER-independent mechanisms." @default.
- W94552537 created "2016-06-24" @default.
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- W94552537 date "2009-04-01" @default.
- W94552537 modified "2023-09-25" @default.
- W94552537 title "Estradiol Differentially Modulates the Growth of Oligodendroglial and Microglial Cells" @default.
- W94552537 doi "https://doi.org/10.1096/fasebj.23.1_supplement.758.2" @default.
- W94552537 hasPublicationYear "2009" @default.
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