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- W945698581 abstract "This chapter focuses on the effects of heterodimeric transcription factor (HIF) activity in the lineage pathways of hematopoietic (including hemangioblast formation) and trophoblast stem (TS) cells. To facilitate continued growth within the hypoxic environment, the cardiovascular and hematopoietic systems are formed and placentation occurs to meet the oxygen (O 2 ) requirements of the embryo. HIF regulates the expression of O 2 -responsive genes involved in energy metabolism, O 2 transport, vasculogenesis, angiogenesis, and hematopoiesis. Loss of HIF activity in Arnt -/- embryos results in lethality caused by cardiovascular, hematopoietic, and placental defects. Although genetic studies have allowed the observation of hypoxic effects on embryonic development and overall pattern formation, in vitro studies using stem cell populations present with mammalian blastocysts have provided a powerful tool to analyze hypoxic effects on cellular differentiation and proliferation. Hypoxia enhances mesoderm and hemangioblast specification during early embryonic development. Severe hypoxia enhances the formation of erythroid bursts from human cord blood cells and the maintenance of BFU-E in vitro. Hypoxia also alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in pre-eclampsia." @default.
- W945698581 created "2016-06-24" @default.
- W945698581 creator A5007317144 @default.
- W945698581 creator A5081437468 @default.
- W945698581 date "2004-01-01" @default.
- W945698581 modified "2023-09-25" @default.
- W945698581 title "Regulation of Hypoxic Genes in Differentiating Stem Cells" @default.
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- W945698581 doi "https://doi.org/10.1016/b978-012436643-5/50016-x" @default.
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