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• W9457906 abstract "New data is gained on the promising trends in the search for neurotropic compounds among GABA derivatives and other members of “GABA shunt” and also among the drugs affecting various stages of this metabolic route. The interactions of various members of “GABA shunt” are studied. The role of GABA-ergic structures of the cerebral cortex in the realization of the effect of benzodiazepine tranquilizers is revealed. The facts obtained suggest that this effect is based on the ability of benzodiazepines to increase the sensitivity of specific postsynaptic receptors to GABA. Antihypoxic action of some of the metabolites of “GABA shunt” is revealed and analyzed from the point of view of its mechanism. The prospects of the practical employment of this effect are illustrated by the example of the sodium salt of gamma-hydroxybutyric acid. Many investigators have proved that gamma-aminobutyrie acid (GABA) is a neurotransmitter of inhibition in the central nervous system of the vertebrates, especially in the cerebral cortex. In addition, being the primary link in the so-called “GABA shunt” or Roberts cycle it contributes to the metabolism (Fig. 1) and thus may affect physiological functions. GABA is mainly located in the central nervous system. During subcellular fractioning endogenous GABA is found in synaptosomes and accumulates in the nerve terminals due to high affinity with sodium-dependent pattern of its uptake. Presence of GABA in synaptosomes and glial cells of the brain may be shown by using autoradiographic method. GABA is formed in the organism in the course of a complex sequence of reactions being a roundabout way between two neighboring links of Krebs cycle: α- ketoglutarate and succinate. - Ketoglutarate subjected to reductive amination is transformed into glutamate which is then decarboxylased. This reaction leading to GABA formation is catalyzed by glutamate decarboxylase (GDC). Transamination of GABA with α - ketoglutarate catalyzed by α - ketoglutarate GABA-aminotransferase (GABA-T) results in the formation of succinic acid semi-aldehyde and glutamate. Succinic semi-aldehyde either reduces into gamma-oxybutyric acid or oxydates into succinic acid which undergoes further changes in the tricarbonic acid cycle." @default.
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• W9457906 date "1979-01-01" @default.
• W9457906 modified "2023-09-23" @default.
• W9457906 title "GABA-ergic Component in the Mechanism of Action of Neurotropic Drugs" @default.
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• W9457906 doi "https://doi.org/10.1016/b978-0-08-023192-1.50027-2" @default.
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