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- W945810958 abstract "Publisher Summary This chapter presents the current understanding of ovarian nitric oxide (NO) as a local regulator of ovulation, oocyte development, and luteal function. Immature ovarian cells synthesized the unique signaling molecule and NO. Ovarian cells synthesize NO and that multiple isoforms of NO synthase (NOS) are expressed in the ovary in a developmental and cell-specific fashion. NO, a lipid and water-soluble gas, is synthesized from the stoichiometric oxidation of one of the guanidino nitrogens of arginine by NO synthase yielding NO and citrulline. NO exerts many of its functions by reacting with metal- and thiol-containing proteins, which can result in both activation and inhibition of target proteins. NO has a short half-life (2-30 s) and the direct measurement of NO production is impractical. NO also has a key function during the luteal phase. The corpus luteum expresses the highest level of ecNOS found during the ovarian cycle and iNOS expression also increases significantly during the late luteal phase. Three important potential functions for luteal NO are regulation of steroidogenesis, angiogenesis, and blood flow." @default.
- W945810958 created "2016-06-24" @default.
- W945810958 creator A5021801448 @default.
- W945810958 date "1999-01-01" @default.
- W945810958 modified "2023-09-27" @default.
- W945810958 title "Ovarian Nitric Oxide: A Local Regulator of Ovulation, Oocyte Maturation Luteal Function" @default.
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- W945810958 doi "https://doi.org/10.1016/s1064-2722(08)60018-3" @default.
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