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- W945935249 abstract "This chapter discusses the X-ray structure of staphylococcal nuclease. It shows views of the structure of the nuclease at three ‘‘levels of resolution”; these structures were determined as follows: (1) At 6 Å resolution, Type I crystals phased from derivatives prepared by soaking in PtCl24- p-chloromercuribenzenesulfonic acid (PCMBS) and p-acetoxymercurianiline (PAMA) and using all the data within a 6 Å sphere in reciprocal space. (2) At 4 Å resolution, again using all the data. (a) Type I crystals phased with the same heavy-atom derivatives. (b) Type II crystals phased with the single substitution of an iodine atom for a methyl group. (3) At high resolution, Type II crystals phased with iodine for methyl and barium for calcium ion substitutions using all the data to 4 Å but only that 35% of the reflections from 4 to 2 Å with the highest intensities. In the Type II crystal the iodine atom was introduced by substituting 5-iododeoxyuridine-3′,5’-diphosphate for pdTp when growing the crystals. For the other derivative the bound calcium ion was replaced by a barium ion by soaking, as it proved difficult to grow large well-formed barium containing crystals de novo. The results indicate that the iodine atom replaces the methyl group and the Ba2+ the Ca2+ with full occupancy and high isomorphicity. There is an indication that the Ba2+ position is somewhat displaced from that of the Ca2+." @default.
- W945935249 created "2016-06-24" @default.
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- W945935249 date "1971-01-01" @default.
- W945935249 modified "2023-10-06" @default.
- W945935249 title "7 Staphylococcal Nuclease X-Ray Structure" @default.
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- W945935249 doi "https://doi.org/10.1016/s1874-6047(08)60367-4" @default.
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