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- W946176880 abstract "flux. Conclusions: Ethanol alone does not stimulate autophagosome formation due to excessive LC3-II delipidation by Atg4. In contrast, ethanol+ low-dose CR pancreatitis decreases Atg4 and stimulates autophagy. Both ethanol and alcoholic pancreatitis cause lysosomal dysfunction resulting in impaired autophagic flux. The results support our 2-hit hypothesis that a combination of 1) autophagy induction, and 2) lysosomal dysfunction causing impaired autophagic flux, are both critical in the mechanism of alcoholic pancreatitis." @default.
- W946176880 created "2016-06-24" @default.
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- W946176880 date "2013-05-01" @default.
- W946176880 modified "2023-09-26" @default.
- W946176880 title "Sa1856 Acute Pancreatitis Alters Synaptic Transmission to Pancreas-Projecting Neurons in the Dorsal Motor Nucleus of the Vagus" @default.
- W946176880 doi "https://doi.org/10.1016/s0016-5085(13)61166-x" @default.
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