FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W946191294> ?p ?o ?g. }

• W946191294 endingPage "95" @default.
• W946191294 startingPage "83" @default.
• W946191294 abstract "The study of an increasing number of processes occurring in the human brain can be carried out on autopsy material. The availability of this material, whether fresh, frozen or fixed, makes it possible to develop methodologies for studying the neuroanatomical and neurochemical aspects of the human brain. It has also become possible in recent years to correlate functional changes with neurochemical changes and with neuroanatomical abnormalities in disease states. Some compounds and structures are damaged irreversibly within minutes after death and some brain components are known to disintegrate within seconds. This led to the widespread idea that autopsy material would not be suitable for basic research purposes and would not supply the necessary answers on the various fundamental questions regarding processes occurring in normal or diseased brain. However, from data published in recent years in which autopsy material has been routinely used, it becomes more and more evident that this is a misconception. There is an increasing number of reports based on the use of normal and pathological human brain tissue obtained by autopsies in spite of the fact that there is a worrying continuous decline in autopsy rate which causes serious concern among scientists world-wide (Anderson and Hill, 1989). It also became evident that when using the proper fixation procedures, sufficient structural integrity is retained in the tissue to allow morphological and morphometrical studies (Swaab and Uylings, 1988). Electron microscopic examination of synaptosomal preparations from post-mortem human brain showed them to be only slightly less pure than preparations from fresh tissue although there was some degree of damage (Hardy et al., 1982). Agonal state effects the stability of brain compounds and causes brain hypoxia. This again forms a tremendous difficulty for the study of human neurological and psychiatric diseases as one of the frequent causes of death is bronchopneumonia which leads to brain hypoxia and results in pronounced lactic acidosis. The Netherlands Brain Bank has succeeded to partly circumvent some of the serious problems encountered in providing human tissue for research by performing rapid autopsies with an average post-mortem delay of 2-4 h. This has become possible by a close collaboration of numerous nursing homes in Amsterdam and its vicinity and with the neuropathologists of the Free University in Amsterdam. We also measure the pH of the tissue as indicator of agonal state in order to reveal unsuitable specimens. The human hypothalamus contains various nuclei manifesting a wide variety of changes in different conditions.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W946191294 created "2016-06-24" @default.
• W946191294 creator A5052712397 @default.
• W946191294 creator A5081867112 @default.
• W946191294 creator A5091598077 @default.
• W946191294 date "1992-01-01" @default.
• W946191294 modified "2023-09-27" @default.
• W946191294 title "Chapter 7 Brain banking and the human hypothalamus — factors to match for, pitfalls and potentials" @default.
• W946191294 cites W1945581482 @default.
• W946191294 cites W1963959128 @default.
• W946191294 cites W1964433896 @default.
• W946191294 cites W1966770839 @default.
• W946191294 cites W1966780020 @default.
• W946191294 cites W1969502847 @default.
• W946191294 cites W1982682496 @default.
• W946191294 cites W1992566356 @default.
• W946191294 cites W1998276240 @default.
• W946191294 cites W2001627376 @default.
• W946191294 cites W2001977373 @default.
• W946191294 cites W2002414447 @default.
• W946191294 cites W2004546223 @default.
• W946191294 cites W2006153277 @default.
• W946191294 cites W2006441699 @default.
• W946191294 cites W2011152523 @default.
• W946191294 cites W2013281474 @default.
• W946191294 cites W2015403170 @default.
• W946191294 cites W2020948281 @default.
• W946191294 cites W2029372047 @default.
• W946191294 cites W2041476819 @default.
• W946191294 cites W2044063584 @default.
• W946191294 cites W2051821298 @default.
• W946191294 cites W2052665207 @default.
• W946191294 cites W2056894155 @default.
• W946191294 cites W2057140016 @default.
• W946191294 cites W2058956962 @default.
• W946191294 cites W2059726698 @default.
• W946191294 cites W2065128301 @default.
• W946191294 cites W2066290173 @default.
• W946191294 cites W2069471416 @default.
• W946191294 cites W2070784027 @default.
• W946191294 cites W2077859295 @default.
• W946191294 cites W2078396742 @default.
• W946191294 cites W2080557271 @default.
• W946191294 cites W2082653087 @default.
• W946191294 cites W2089650868 @default.
• W946191294 cites W2090547531 @default.
• W946191294 cites W2091008378 @default.
• W946191294 cites W2091546759 @default.
• W946191294 cites W2114858299 @default.
• W946191294 cites W2115421845 @default.
• W946191294 cites W2561857908 @default.
• W946191294 doi "https://doi.org/10.1016/s0079-6123(08)64565-3" @default.
• W946191294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1480765" @default.
• W946191294 hasPublicationYear "1992" @default.
• W946191294 type Work @default.
• W946191294 sameAs 946191294 @default.
• W946191294 citedByCount "94" @default.
• W946191294 countsByYear W9461912942012 @default.
• W946191294 countsByYear W9461912942013 @default.
• W946191294 countsByYear W9461912942014 @default.
• W946191294 countsByYear W9461912942015 @default.
• W946191294 countsByYear W9461912942016 @default.
• W946191294 countsByYear W9461912942017 @default.
• W946191294 countsByYear W9461912942018 @default.
• W946191294 countsByYear W9461912942020 @default.
• W946191294 countsByYear W9461912942021 @default.
• W946191294 countsByYear W9461912942023 @default.
• W946191294 crossrefType "book-chapter" @default.
• W946191294 hasAuthorship W946191294A5052712397 @default.
• W946191294 hasAuthorship W946191294A5081867112 @default.
• W946191294 hasAuthorship W946191294A5091598077 @default.
• W946191294 hasConcept C142724271 @default.
• W946191294 hasConcept C169760540 @default.
• W946191294 hasConcept C207886595 @default.
• W946191294 hasConcept C25876315 @default.
• W946191294 hasConcept C2777670902 @default.
• W946191294 hasConcept C2779504383 @default.
• W946191294 hasConcept C2986936838 @default.
• W946191294 hasConcept C42407357 @default.
• W946191294 hasConcept C71924100 @default.
• W946191294 hasConcept C86803240 @default.
• W946191294 hasConceptScore W946191294C142724271 @default.
• W946191294 hasConceptScore W946191294C169760540 @default.
• W946191294 hasConceptScore W946191294C207886595 @default.
• W946191294 hasConceptScore W946191294C25876315 @default.
• W946191294 hasConceptScore W946191294C2777670902 @default.
• W946191294 hasConceptScore W946191294C2779504383 @default.
• W946191294 hasConceptScore W946191294C2986936838 @default.
• W946191294 hasConceptScore W946191294C42407357 @default.
• W946191294 hasConceptScore W946191294C71924100 @default.
• W946191294 hasConceptScore W946191294C86803240 @default.
• W946191294 hasLocation W9461912941 @default.
• W946191294 hasLocation W9461912942 @default.
• W946191294 hasOpenAccess W946191294 @default.
• W946191294 hasPrimaryLocation W9461912941 @default.
• W946191294 hasRelatedWork W1540104393 @default.
• W946191294 hasRelatedWork W2013281474 @default.
• W946191294 hasRelatedWork W2038754388 @default.

• next