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- W946301076 abstract "This chapter elaborates the importance of the inhibitors of folate biosynthesis and utilization in chemotherapy. The exploration of enzymes and metabolic pathways by means of antimetabolites has been productive of both new medicinal agents and advances in fundamental knowledge. The rationale for its use in combination with a sulfonamide is stated. The target is the microbial pool of tetrahydrofolate cofactors that are essential to the metabolism and multiplication of the microbial cell. Such cofactors occur ubiquitously and perform the synthesis of serine and the methylation of homocysteine to form methione. Microorganisms employ similar reactions in the biosynthesis of riboflavin, pantothenate, thiamin, and dihydrofolate itself. The application of a spectrum of inhibitors to a selection of partially purified reductases documented their mechanism of action and revealed the magnitude of their differential affinities for the reductases of different species. Trimethoprim represents the culmination of an effort to tailor a molecule for maximum binding to bacterial reductases with minimum binding to mammalian reductase." @default.
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- W946301076 date "1972-01-01" @default.
- W946301076 modified "2023-09-27" @default.
- W946301076 title "Inhibitors of Folate Biosynthesis and Utilization – Evolutionary Changes as a Basis for Chemotherapy" @default.
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- W946301076 doi "https://doi.org/10.1016/s0065-7743(08)60795-2" @default.
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