FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W946658644> ?p ?o ?g. }

• W946658644 abstract "This study was designed to investigate whether the red cell aggregation depends on its initial level under drug therapy or cell incubation with bioactive chemical compounds. Sixty six subjects were enrolled onto this study, and sub-divided into two groups: the first group of patients (n = 36) with cerebral atherosclerosis received pentoxifylline therapy (400 mg, thrice daily) for 4 weeks. The patients of the second group were initially treated with Epoetin beta 10,000 units subcutaneously thrice a week, for 4 weeks. The second group - adult anemic patients (n = 30) with the confirmed diagnosis of solid cancer (Hb < 100 g/L). After 4 weeks of pentoxifylline treatment the red cell aggregation increased (p < 0.05) in the patients with initially low RBCA. On the other hand in the patients with initially high RBCA treatment with pentoxifylline reduced it markedly (p < 0.01). In vitro experiments with pentoxifylline RBC incubation resulted in a decrease of the initially high RBCA by 47% (p < 0.01), whereas in the sub-group with initially low RBCA it increased. It was observed that after 4 weeks of epoetin-beta treatment 75% the anemic patients with initially high RBCA had an aggregation lowering. The drop of aggregation was about 34% (p < 0.01). At the same time 25% of the study patients had a significant RBCA increase (p < 0.05) after treatment. The initially low red cell aggregation after incubation with epoetin-beta was markedly increased by 122% (p < 0.05). On the contrary initially high RBCA was reduced by 47% (p < 0.05). When forskolin (10 μM) was added to the RBC suspensions the RBCA was increased in sub-group of subjects with initially low aggregation and it was decreased in sub-group with initially high one. The similar RBCA changes were observed when RBC suspensions were incubated with vinpocetine, calcium ionophore (A23187), Phorbol 12-myristate 13-acetate (PMA) as a protein kinase C (PKC) stimulator. A major finding of this study is that the red cell aggregation effects of some drugs depend markedly on the initial, pre-treatment aggregation status of the patients. These results demonstrate that the different red blood cell aggregation responses to the biological stimuli depend strongly on the initial, pre-treatment status of the subject and the most probably it is connected with the crosstalk between the adenylyl cyclase signaling pathway and Ca2+ regulatory mechanism." @default.
• W946658644 created "2016-06-24" @default.
• W946658644 creator A5011377350 @default.
• W946658644 creator A5053274972 @default.
• W946658644 creator A5054686207 @default.
• W946658644 creator A5055925178 @default.
• W946658644 creator A5061618508 @default.
• W946658644 creator A5071249250 @default.
• W946658644 date "2011-01-01" @default.
• W946658644 modified "2023-09-27" @default.
• W946658644 title "Red blood cell aggregation changes are depended on its initial value: Effect of long-term drug treatment and short-term cell incubation with drug" @default.
• W946658644 cites W116793510 @default.
• W946658644 cites W1516545417 @default.
• W946658644 cites W1540582533 @default.
• W946658644 cites W1589688496 @default.
• W946658644 cites W1634547101 @default.
• W946658644 cites W1668755942 @default.
• W946658644 cites W1716855656 @default.
• W946658644 cites W1811974231 @default.
• W946658644 cites W186519912 @default.
• W946658644 cites W189926028 @default.
• W946658644 cites W1917458716 @default.
• W946658644 cites W1972530107 @default.
• W946658644 cites W1981083054 @default.
• W946658644 cites W1993195400 @default.
• W946658644 cites W2000604723 @default.
• W946658644 cites W2002429570 @default.
• W946658644 cites W2004778528 @default.
• W946658644 cites W2024545956 @default.
• W946658644 cites W2041000554 @default.
• W946658644 cites W2047177892 @default.
• W946658644 cites W2063423031 @default.
• W946658644 cites W2083112746 @default.
• W946658644 cites W2093025457 @default.
• W946658644 cites W2095724354 @default.
• W946658644 cites W2110021778 @default.
• W946658644 cites W2139494794 @default.
• W946658644 cites W2141679899 @default.
• W946658644 cites W2154891614 @default.
• W946658644 cites W2155154942 @default.
• W946658644 cites W2156215631 @default.
• W946658644 cites W2164127075 @default.
• W946658644 cites W2165474821 @default.
• W946658644 cites W2307195668 @default.
• W946658644 cites W2399547768 @default.
• W946658644 cites W25318626 @default.
• W946658644 cites W64852952 @default.
• W946658644 cites W852894586 @default.
• W946658644 cites W85695413 @default.
• W946658644 cites W941301238 @default.
• W946658644 cites W949575744 @default.
• W946658644 doi "https://doi.org/10.3233/ch-2011-1415" @default.
• W946658644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22012828" @default.
• W946658644 hasPublicationYear "2011" @default.
• W946658644 type Work @default.
• W946658644 sameAs 946658644 @default.
• W946658644 citedByCount "6" @default.
• W946658644 countsByYear W9466586442016 @default.
• W946658644 countsByYear W9466586442017 @default.
• W946658644 countsByYear W9466586442021 @default.
• W946658644 crossrefType "journal-article" @default.
• W946658644 hasAuthorship W946658644A5011377350 @default.
• W946658644 hasAuthorship W946658644A5053274972 @default.
• W946658644 hasAuthorship W946658644A5054686207 @default.
• W946658644 hasAuthorship W946658644A5055925178 @default.
• W946658644 hasAuthorship W946658644A5061618508 @default.
• W946658644 hasAuthorship W946658644A5071249250 @default.
• W946658644 hasConcept C126322002 @default.
• W946658644 hasConcept C134018914 @default.
• W946658644 hasConcept C141071460 @default.
• W946658644 hasConcept C185592680 @default.
• W946658644 hasConcept C25642318 @default.
• W946658644 hasConcept C2776557347 @default.
• W946658644 hasConcept C2776694085 @default.
• W946658644 hasConcept C2777208419 @default.
• W946658644 hasConcept C2780035454 @default.
• W946658644 hasConcept C2780404050 @default.
• W946658644 hasConcept C42219234 @default.
• W946658644 hasConcept C55493867 @default.
• W946658644 hasConcept C71924100 @default.
• W946658644 hasConcept C90924648 @default.
• W946658644 hasConcept C98274493 @default.
• W946658644 hasConceptScore W946658644C126322002 @default.
• W946658644 hasConceptScore W946658644C134018914 @default.
• W946658644 hasConceptScore W946658644C141071460 @default.
• W946658644 hasConceptScore W946658644C185592680 @default.
• W946658644 hasConceptScore W946658644C25642318 @default.
• W946658644 hasConceptScore W946658644C2776557347 @default.
• W946658644 hasConceptScore W946658644C2776694085 @default.
• W946658644 hasConceptScore W946658644C2777208419 @default.
• W946658644 hasConceptScore W946658644C2780035454 @default.
• W946658644 hasConceptScore W946658644C2780404050 @default.
• W946658644 hasConceptScore W946658644C42219234 @default.
• W946658644 hasConceptScore W946658644C55493867 @default.
• W946658644 hasConceptScore W946658644C71924100 @default.
• W946658644 hasConceptScore W946658644C90924648 @default.
• W946658644 hasConceptScore W946658644C98274493 @default.
• W946658644 hasLocation W9466586441 @default.
• W946658644 hasLocation W9466586442 @default.
• W946658644 hasOpenAccess W946658644 @default.

• next