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- W94677191 abstract "The anterior pituitary is a well-characterized and accessible model for studying cellspecific gene activation and the process by which distinct cell-types develop within an organ (1–3). Accordingly, the development of the pituitary gland has been a topic of particularly intense interest by molecular biologists and developmental biologists, as well as endocrinologists. Over the last few years, this activity has yielded remarkable progress in identifying crucial factors involved in anterior pituitary gene expression and development. However, there is an underlying dilemma in the study of pituitary development—namely, that the various pituitary cell types are currently recognizable only by the hormones they synthesize. Therefore, the distinction between factors that promote expression of the hormone gene (i.e., permit recognition of the cell type) and those which direct other facets of cell type differentiation is often blurred. In this chapter, we will review the current state of knowledge regarding the components required for normal development of the pituitary gland and its distinct cell types. Since the ontogeny of the pituitary has been most extensively examined in laboratory rodents, the data we present will be derived predominately from studies in the mouse and rat. However, the appearance of anatomical structures, hormones, and regulatory factors in the human appear to follow relatively similar patterns and where possible, we will include relevant information on human pituitary development and point out where differences are thought to exist.KeywordsLeukemia Inhibitory FactorAnterior PituitaryPituitary CellPituitary DevelopmentPituitary Cell TypeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W94677191 created "2016-06-24" @default.
- W94677191 creator A5007232966 @default.
- W94677191 creator A5077470996 @default.
- W94677191 date "1999-01-01" @default.
- W94677191 modified "2023-09-24" @default.
- W94677191 title "Molecular Aspects of Pituitary Development" @default.
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